Skip to main content
SpringerLink
Log in

Development and use of a TG-DTA-microscope for evaluation of pharmaceutical materials

  • Published:
Journal of Thermal Analysis and Calorimetry Aims and scope Submit manuscript

Abstract

The successful combination of microscopy with thermogravimetry-differential thermal analysis is reported. Simultaneous use of all three techniques is made possible by custom fitting a quartz glass window into the furnace of a commercially available TG-DTA. The quartz window enabled direct observations from a microscope mounted above the furnace throughout the entirety of the thermal analytical experiments. Several examples are provided for the use of this combined system for evaluating dehydrations, degradation and phase conversions in pharmaceutical materials. In some examples, microscopy provided information not accessible from the thermal analytical data alone. In others, the thermal analytical data was more informative than the microscopy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. JK Haleblian WJ McCrone (1969) J. Pharm. Sci. 58 911 Occurrence Handle1:CAS:528:DyaF1MXltVGitrw%3D

    CAS  Google Scholar 

  2. JK Haleblian (1975) J. Pharm. Sci. 64 1269 Occurrence Handle1:CAS:528:DyaE2MXltlKkt7k%3D

    CAS  Google Scholar 

  3. D Giron (1995) Thermochim. Acta 248 1 Occurrence Handle1:CAS:528:DyaK2MXivVOrtr8%3D Occurrence Handle10.1016/0040-6031(94)01953-E

    Article  CAS  Google Scholar 

  4. HG Brittain et al. (1999) Polymorphism in Pharmaceutical Solids Marcel Dekker, Inc. New York

    Google Scholar 

  5. GGZ Zhang D Law EA Schmitt Y Qiu (2004) Adv. Drug Deliv. Rev. 56 372 Occurrence Handle10.1016/j.addr.2003.10.009

    Article  Google Scholar 

  6. D Giron M Mutz S Garnier (2004) J. Therm. Anal. Cal. 77 709 Occurrence Handle1:CAS:528:DC%2BD2cXmvFSmtLo%3D Occurrence Handle10.1023/B:JTAN.0000039005.51343.33

    Article  CAS  Google Scholar 

  7. D Giron (2002) J. Therm. Anal. Cal. 68 335 Occurrence Handle1:CAS:528:DC%2BD38XkvFehurk%3D Occurrence Handle10.1023/A:1016015113795

    Article  CAS  Google Scholar 

  8. IM Vitéz (2004) J. Therm. Anal. Cal. 78 33 Occurrence Handle10.1023/B:JTAN.0000042151.60566.0f

    Article  Google Scholar 

  9. UJ Griesser D Weigand JM Rollinger M Haddow E Gstrein (2004) J. Therm. Anal. Cal. 77 511 Occurrence Handle1:CAS:528:DC%2BD2cXmvFSmtbk%3D Occurrence Handle10.1023/B:JTAN.0000038990.43475.db

    Article  CAS  Google Scholar 

  10. MR Caira A Foppoli ME Sangalli L Zema F Giordano (2004) J. Therm. Anal. Cal. 77 653 Occurrence Handle1:CAS:528:DC%2BD2cXmvFSmtLY%3D Occurrence Handle10.1023/B:JTAN.0000039001.05945.42

    Article  CAS  Google Scholar 

  11. MR Caira SA Bourne CL Oliver (2004) J. Therm. Anal. Cal. 77 597 Occurrence Handle1:CAS:528:DC%2BD2cXmvFSmtbw%3D Occurrence Handle10.1023/B:JTAN.0000038997.18925.b3

    Article  CAS  Google Scholar 

  12. EV Boldyreva VA Drebushchak IE Paulkov YA Kovalevskaya TN Drebushchak (2004) J. Therm. Anal. Cal. 77 607 Occurrence Handle1:CAS:528:DC%2BD2cXmvFSmtLc%3D Occurrence Handle10.1023/B:JTAN.0000038998.47606.27

    Article  CAS  Google Scholar 

  13. S Pfeffer-Hennig P Poechon M Bellus C Goldbronn E Tedesco (2004) J. Therm. Anal. Cal. 77 663 Occurrence Handle1:CAS:528:DC%2BD2cXmvFSmtLs%3D Occurrence Handle10.1023/B:JTAN.0000039002.79914.b7

    Article  CAS  Google Scholar 

  14. CFS Arãgao JMB Filho RO Macedo (2001) J. Therm. Anal. Cal. 64 185 Occurrence Handle10.1023/A:1011593214548

    Article  Google Scholar 

  15. FS de Souza APG Barreto RO Macedo (2001) J. Therm. Anal. Cal. 64 739 Occurrence Handle10.1023/A:1011548512655

    Article  Google Scholar 

  16. RO Macedo TG do Nascimento JWE Veras (2002) J. Therm. Anal. Cal. 67 483 Occurrence Handle1:CAS:528:DC%2BD38Xit1CmsLs%3D Occurrence Handle10.1023/A:1013901332759

    Article  CAS  Google Scholar 

  17. M. Wagner and M. Schubnell, Proceedings of the 32nd NATAS Conference, 2004, p. 122.

  18. W. J. Collins, C. DuBois, R. T. Cambron and N. L. Redman-Furey, Proceedings of the 31st NATAS Conference, 2003.

  19. WJ Collins RT Cambron N Redman-Furey A Bigalow-Kern (2005) J. ASTM Int. 2 JAI 12789 Occurrence Handle10.1520/JAI12789

    Article  Google Scholar 

  20. B Burger (1982) Acta Pharm. Technol. 28 1 Occurrence Handle1:CAS:528:DyaL38Xks1SqsL4%3D

    CAS  Google Scholar 

  21. N. L. Redman-Furey, W. J. Collins and M. A. Burgin, Proceedings of the 30th NATAS Conference, 2002, p. 733.

  22. NL Redman-Furey ML Dicks J Godlewski DC Vaughn WJ Collins (2005) J. ASTM Int. 2 JAI 12972

    Google Scholar 

  23. NL Redman-Furey M Dicks AS Bigalow-Kern RT Cambron G Lubey C Lester D Vaughn (2005) J. Pharm. Sci. 94 893 Occurrence Handle1:CAS:528:DC%2BD2MXjtFCju7o%3D Occurrence Handle10.1002/jps.20308

    Article  CAS  Google Scholar 

  24. AS Bigalow-Kern RT Cambron WJ Collins C DuBois NL Redman-Furey (2005) J. ASTM Int. 2 JAI 12790

    Google Scholar 

  25. A. S. Bigalow-Kern, K. B. Poiesz, R. T. Cambron, C. L. Grundner and N. L. Redman-Furey, Proceedings of the 33rd NATAS Conference, 2005.

Download references

Author information

Authors and Affiliations

  1. Procter & Gamble Pharmaceuticals, Inc., Norwich, New York, USA, 191, 13815

    Grundner Carol L., Poiesz Kate B. & Redman-Furey Nancy L.

Authors
  1. Grundner Carol L.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Poiesz Kate B.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Redman-Furey Nancy L.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Grundner Carol L..

Rights and permissions

Reprints and permissions

About this article

Cite this article

Grundner, C.L., Poiesz, K.B. & Redman-Furey, N.L. Development and use of a TG-DTA-microscope for evaluation of pharmaceutical materials. J Therm Anal Calorim 85, 91–98 (2006). https://doi.org/10.1007/s10973-005-7352-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10973-005-7352-x

Keywords

Search

Navigation