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Light and Electron Microscopy

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Analytical Techniques in the Pharmaceutical Sciences

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

Microscopic techniques have a long history in pharmaceutical formulation research and development. They are especially useful for the study of systems containing particles of different length scales (like powders, granules, or colloidal suspensions) but can also be employed for the study of compact solid forms like tablets or of semisolids. As they yield a visual impression of the object of study they provide a rather natural way to the comprehension of sample behavior. As with all analytical techniques, however, there may be limitations and pitfalls that should be known in order to employ the methods correctly. This chapter explains the basic features of the microscopic techniques traditionally employed in pharmaceutical research—optical light microscopy as well as scanning and transmission electron microscopy with their respective variations. Apart from a short overview on instrumentation, the different sample preparation techniques are explained and a selection of pharmaceutical application examples is provided to illustrate the wealth of information that can be obtained and to stimulate a more detailed exploration of the possibilities of these fascinating methods.

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Authors and Affiliations

  1. Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Mendelssohnstraße 1, Braunschweig, 38106, Germany

    Heike Bunjes

  2. Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, Odense, M 5230, Denmark

    Judith Kuntsche

Authors
  1. Heike Bunjes
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  2. Judith Kuntsche
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Correspondence to Heike Bunjes .

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Editors and Affiliations

  1. Bioneer: FARMA Department of Pharmacy, University of Copenhagen, Copenhagen Ø, Denmark

    Anette Müllertz

  2. Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, Seychelles

    Yvonne Perrie

  3. Department of Pharmacy, University of Copenhagen, Copenhagen Ø, Denmark

    Thomas Rades

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Bunjes, H., Kuntsche, J. (2016). Light and Electron Microscopy. In: Müllertz, A., Perrie, Y., Rades, T. (eds) Analytical Techniques in the Pharmaceutical Sciences. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-4029-5_16

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