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Isothermal titration calorimetry (ITC) method to study drug/ion exchanger interaction

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Abstract

An isothermal titration calorimetry (ITC) method to measure the heat effects evolving from the binding between cation exchanger Amberlite ® IRP 69 and the cationic drug substances propranolol hydrochloride (PROP), metoprolol tartarate (METO), acebutolol hydrochloride (ACEB) and chlorpheniramine maleate (CPR) has been developed. The method gives repeatable results with an error about 5% for the beta-blockers PROP, METO and ACEB, and about 10% for the antihistamine CPR.

The calculation of the thermodynamic parameters enthalpy change (ΔHbind) and Gibbs free energy change (ΔGbind) show significant differences between the different drug substances.

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  1. Faculty of Health Science, Nord-Trřndelag University College, Namsos, Norway, 7800

    Zeiss D  & Bauer-Brandl A

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  1. Zeiss D
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  2. Bauer-Brandl A
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Correspondence to Zeiss D .

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Zeiss, D., Bauer-Brandl, A. Isothermal titration calorimetry (ITC) method to study drug/ion exchanger interaction . J Therm Anal Calorim 83, 309–312 (2006). https://doi.org/10.1007/s10973-005-7234-2

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  • DOI: https://doi.org/10.1007/s10973-005-7234-2

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