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Iron-doped calcium silicate bone cement loaded with carboxymethyl chitosan for bone tissue engineering repair materials

  • Original Paper: Nano-structured materials (particles, fibers, colloids, composites, etc.)
  • Published:
Journal of Sol-Gel Science and Technology Aims and scope Submit manuscript

Abstract

The tricalcium silicate (C3S) bone cement has excellent osteogenic properties and is expected to be a material for repairing bone defects. However, the alkalinity of C3S after hydration is too high and the antibacterial activity is insufficient. Therefore, C3S was modified to further improve its application performance. The physical and chemical properties of tricalcium ferrosilicate bone cement soaked in carboxymethyl chitosan (CMCS) were studied, and the biological activity and antibacterial properties of the composite bone cement were evaluated. The results showed that C3S containing 5 mol% Fe3+ and 5%m/v CMCS exhibited good self-setting behavior, compressive strength, degradation rate, and mineralization ability in vitro. Cell experiment in vitro stated clearly that the material was suitable for cell survival and proliferation for a long time. The antibacterial test showed that 5Fe-5CMCS had excellent inhibitory effect on E. coli and S. aureus, and the antibacterial ratio was 27.65 ± 2.03% and 36.70 ± 2.14%, respectively. Therefore, Fe-doped calcium silicate loaded with CMCS is considered to be a promising material for bone defect treatment.

Graphical Abstract

Process of synthesizing bone cement by sol-gel method.

Highlights

  • A simple and convenient sol-gel method was used to synthesize a new type silicon-based bone material.

  • The effect of Fe3+ and CMCS content on the physical and chemical properties of C3S cement was studied.

  • Modified C3S cement has good biological activity, cell compatibility, and bacteriostasis.

  • The modified 5Fe-5MCS bone cement is expected to be an ideal material for repairing bone defects.

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Acknowledgements

This work was financially supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, and the Postgraduate Research & Practice Innovation Program of Jiangsu Province.

Author contributions

AW: Study design, data analysis, and writing. WD: Experimental design. YZ: Data analysis. ZZ: Visualization and investigation. YZ: Writing the manuscript. JL: Research questions. YZ: Conceptualization, Supervision, Project administration, Reviewing, and Editing.

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Authors and Affiliations

  1. College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 211816, China

    Anping Wang, Yanan Zhang, Zilong Zhang, Yuhan Zou, Jiapan Luan & Yin Zhang

  2. Department of anesthesiology, Zhongda Hospital Southeast University, Nanjing, 210009, China

    Wanqiu Du

  3. Nanjing Haoqi Advanced Materials Co., Ltd, Nanjing, 211300, China

    Yin Zhang

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  1. Anping Wang
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Correspondence to Yanan Zhang or Yin Zhang.

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Wang, A., Du, W., Zhang, Y. et al. Iron-doped calcium silicate bone cement loaded with carboxymethyl chitosan for bone tissue engineering repair materials. J Sol-Gel Sci Technol 106, 44–53 (2023). https://doi.org/10.1007/s10971-023-06062-5

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