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Fluoride release and uptake characteristics of the sol-gel derived glass ionomer cement modified with fluoride containing strontium-based bioactive glass nanoparticles

  • Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications
  • Published:
Journal of Sol-Gel Science and Technology Aims and scope Submit manuscript

Abstract

A steady release of fluoride from restorative dental materials has been known to prevent secondary caries. The common glass ionomer cement has provided high fluoride release in the first period, but this results in short-term fluoride release. The ionomer glass synthesized by the sol-gel method with improving fluoride release and uptake ability was developed in this study. Fluoride containing strontium-based bioactive glass (BGF) was added to the sol-gel derived glass ionomer cement (SGIC) to increase the ability to release and uptake fluoride. The mechanism of the fluoride release and uptake was determined using fluoride ion-selective electrodes (F-ISE), scanning electron microscopy coupled with energy-dispersive x-ray spectroscopy (SEM-EDS) techniques, and x-ray photoelectron spectroscopy (XPS). The setting time, compressive strength, and cytotoxicity of SGIC and SGIC adding BGF were also determined. The results of this investigation showed that the SGIC had a high potential to release and absorb fluoride as compared with the commercial GIC. The addition of BGF to SGIC could significantly improve both fluoride release and SGIC uptake ability since the BGF could reserve the fluoride ions inside their porous structure. Moreover, the addition of 1 wt.% BGF to SGIC resulted in an increase in compressive strength without affecting the setting time. In vitro cell viability of NIH/3T3 fibroblast cells also showed less cytotoxicity for SGIC with 1 wt.% BGF, which offered a potential advantage in clinical use.

Graphical Abstract

Highlights

  • The ionomer glass belonging to the system 4.5SiO2-4Al2O3-0.45P2O5-2CaO-2F2 and the bioactive glass using as an additive belonging to the system 45SiO2-5P2O5-35SrO-15SrF2 were successfully synthesized by the sol-gel method.

  • XPS result demonstrated that the formation of Al-F complex in the SGIC sample played an important role in fluoride release and uptake ability.

  • BGF additive was found to have the ability to reserve free fluoride ions inside its porous structure, which could enhance its ability to release and uptake fluoride into SGIC.

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Acknowledgements

The authors would like to thank the Synchrotron Light Research Institute (Public Organization), Thailand for the XPS (BL5.3) facilities and their help in the data analysis and Suranaree University of Technology, Thailand for the facilities to complete this work.

Funding

This paper was financially supported by SUT Research and Development Fund.

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Authors and Affiliations

  1. School of Ceramic Engineering, Institute of Engineering, Suranaree University of Technology, 111 University Avenue, Muang District, Nakhon Ratchasima, 30000, Thailand

    Oranich Thongsri, Sawitri Srisuwan, Paritat Thaitalay, Rawee Dangwiriyakul & Sirirat Tubsungnoen Rattanachan

  2. Synchrotron Light Research Institute (Public Organization), Nakhon Ratchasima, Thailand

    Narong Chanlek

  3. School of Biochemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand

    Chutima Talabnin

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  1. Oranich Thongsri
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Contributions

The study conception and design were contributed by OT and STR. OT, SS, PT, and RD were in charge of material preparation, data collecting, and analysis. The evaluation of XPS technique and data analysis were performed by NC. The cytotoxicity testing was performed by CT. The first draft of the manuscript was written by OT and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Sirirat Tubsungnoen Rattanachan.

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Thongsri, O., Srisuwan, S., Thaitalay, P. et al. Fluoride release and uptake characteristics of the sol-gel derived glass ionomer cement modified with fluoride containing strontium-based bioactive glass nanoparticles. J Sol-Gel Sci Technol 105, 857–870 (2023). https://doi.org/10.1007/s10971-023-06061-6

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