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Preparation of PVA/starch hydrogel and its in-vitro drug release potential against pus-inducing pathogenic strain and breast cancer cell line

  • Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications
  • Published:
Journal of Sol-Gel Science and Technology Aims and scope Submit manuscript

Abstract

The starch was blended with poly(vinyl) alcohol (PVA) to develop PVA/starch (PS) hydrogel. The physical interaction of PVA with starch was concluded by FTIR and XRD techniques. The thermal decomposition behavior of PS hydrogel was analyzed by thermogravimetric analysis. The swelling index and moisture loss analysis was carried out to comprehend the water absorption and retention behavior of PS hydrogel. The PS hydrogel was biocompatible with RBC due to its lower hemolysis value. The curcumin-loaded PS hydrogel showed an excellent anticancer activity against breast cancer cell line. The antibacterial activity of cephalosporin-loaded PS hydrogel was evaluated against the Staphylococcus aureus.

Graphical abstract

Highlights

  • The PVA/mannitol hydrogel was prepared to study its drug delivery potential.

  • The PM hydrogel effectively delivered the drugs against MCF-7 and pathogenic strains.

  • The PM hydrogel exhibited an excellent water retention ability.

  • The prepared PM hydrogel was non-hemolytic to red blood cells.

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Authors and Affiliations

  1. Department of Food Technology, Hindustan Institute of Technology and Science, Padur, 603103, Tamil Nadu, India

    P. Sankarganesh

  2. Department of Physics, Hindustan Institute of Technology and Science, Padur, 603103, Tamil Nadu, India

    V. Parthasarathy

  3. Centre for Research & Consultancy, Department of Microbiology, Hindustan College of Arts & Science, Padur, 603103, Tamil Nadu, India

    A. Ganesh Kumar, S. Ragu, M. Saraniya & N. Udayakumari

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  1. P. Sankarganesh
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  2. V. Parthasarathy
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  3. A. Ganesh Kumar
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  4. S. Ragu
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Correspondence to V. Parthasarathy.

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Sankarganesh, P., Parthasarathy, V., Kumar, A.G. et al. Preparation of PVA/starch hydrogel and its in-vitro drug release potential against pus-inducing pathogenic strain and breast cancer cell line. J Sol-Gel Sci Technol 101, 571–578 (2022). https://doi.org/10.1007/s10971-022-05735-x

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  • DOI: https://doi.org/10.1007/s10971-022-05735-x

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