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Hierarchical meso–macroporous bioglass for bone tissue engineering

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Abstract

A novel meso–macroporous bioglass has been synthesized based on a sol–gel technique. This method used mushroom stalk as macroporous template and EO20PO70EO20 as the mesoporous template. The final sample has copied the macroporous structure of the plant template, precisely. Ibuprofen was used as the model drug, and the drug loading and release test indicated the loading amount of the sample could reach 33.59 wt% and the releasing amount closed 75 wt% after 48 h. The excellent biomineralization and bioactive are also confirmed in vitro tests. It takes only 4 h to induce the formation of hydroxyapatite. Notably, the biocompatibility assessment confirmed that the obtained materials presented good biocompatibility and the enhanced adherence of HeLa cells. The exquisite mesoporous structure of the sample would be propitious to storage and transport guest molecule, making the hierarchical porous materials have more distinctive performance and application on bone tissue regeneration and drug delivery, etc.

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Acknowledgments

Financial support for this study was provided by the National Natural Science Foundation of China (21171045, 21101046), Natural Science Foundation of Heilongjiang Province of China (ZD201214), Program for Scientific and Technological Innovation team Construction in Universities of Heilongjiang Province (2011TD010), Research Fund for the Doctoral Program of Higher Education of China (20102329110002), Pre-research Found for Technological Development of Harbin Normal University (12XYG-11), Foundation of Harbin Educational Committee (12511168), Innovation special fund of Harbin Science and Technology Bureau of China (KGB201014).

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 150025, People’s Republic of China

    Xiao Han, Xiaofeng Li, Huiming Lin, Jie Ma, Xiang Chen, Chunhui Bian, Xiaodan Wu & Fengyu Qu

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  1. Xiao Han
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  2. Xiaofeng Li
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  3. Huiming Lin
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  4. Jie Ma
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  5. Xiang Chen
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  6. Chunhui Bian
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  7. Xiaodan Wu
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  8. Fengyu Qu
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Correspondence to Fengyu Qu.

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Han, X., Li, X., Lin, H. et al. Hierarchical meso–macroporous bioglass for bone tissue engineering. J Sol-Gel Sci Technol 70, 33–39 (2014). https://doi.org/10.1007/s10971-014-3270-3

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  • DOI: https://doi.org/10.1007/s10971-014-3270-3

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