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A co-templated approach to hierarchically mesoporous–macroporous bioactive glasses (MMBG) scaffolds for bone tissue regeneration

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Abstract

In this paper, one kind of well-ordered hierarchical mesoporous–macroporous bioactive glasses (MMBG) scaffolds with large pore size of 60–120 μm and mesoporous phase in inner-wall has synthesized successfully. This method used stem core of corn as macroporous template and P123 as mesoporous template. The final samples have replicated the structure of the macroporous plant templates precisely. Since the aperture and pore structure of different plants are variable, it provides a possible way for the synthesis of materials with various aperture holes and pore structure. The organizational structure of final sample is benefit to transport and storage guest molecule, making these hierarchical porous materials have more superior performance and application in the field of macromolecules separation, bone tissue regeneration, and drug delivery, etc. The in vitro tests indicated hierarchical MMBG scaffolds have well capacity for inducing the HA growth. They have the potential to satisfy the demands of bone tissue engineering regeneration.

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Acknowledgments

Financial support for this study was provided by the National Native Science Foundation of China (21171045, 21101046),Innovation special fund of Harbin Science and Technology Bureau of China (2010RFXXS055),Program for Scientific and Technological Innovation team Construction in Universities of Heilongjiang province (2011TD010),and Doctoral Initiation Fund of Harbin Normal University (KGB201006).

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 150025, People’s Republic of China

    Huiming Lin, Jinyan Ma, Xiaofeng Li, Xiang Wu & Fengyu Qu

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  1. Huiming Lin
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  2. Jinyan Ma
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  3. Xiaofeng Li
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  4. Xiang Wu
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  5. Fengyu Qu
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Correspondence to Fengyu Qu.

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Lin, H., Ma, J., Li, X. et al. A co-templated approach to hierarchically mesoporous–macroporous bioactive glasses (MMBG) scaffolds for bone tissue regeneration. J Sol-Gel Sci Technol 62, 170–176 (2012). https://doi.org/10.1007/s10971-012-2705-y

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