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Nanoparticle-based theranostics in nuclear medicine

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Abstract

Nuclear medicine has revolutionized medical diagnostic and therapeutic interventions by employing radiopharmaceuticals for detection and treatment. However, the limited selectivity and efficacy of traditional radiopharmaceuticals call for novel approaches to enhance the precision and therapeutic potential of nuclear medicine. Application of nanoparticle-mediated radiopharmaceuticals in treatment and diagnostics (theranostics) integrates imaging and therapeutic modalities into a single nanoscale platform to address these challenges and open new insights. This review study comprehensively explores the recent improvements in nanoparticle-based theranostics for nuclear medicine applications. In this regard, the fundamentals of nuclear medicine and the significance of combining imaging and therapy are introduced. Moreover, in this context, we evaluated the challenges of nanoparticle-based theranostics, especially from the viewpoint of toxicity and immunogenicity.

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Author information

Authors and Affiliations

  1. Department of Anatomy, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

    Herlina Uinarni

  2. Radiology Department of Pantai, Indah Kapuk Hospital, Jakarta, Indonesia

    Herlina Uinarni

  3. Department of Pharmacy, Kut University College, Kut, Wasit, 52001, Iraq

    Wesam R. Kadhum

  4. Advanced Research Center, Kut University College, Kut, Wasit, 52001, Iraq

    Wesam R. Kadhum

  5. Department of Medical Laboratory Techniques, Al-Maarif University College, Al-Anbar, Iraq

    Raed Obaid Saleh

  6. College of Technical Engineering, the Islamic University, Najaf, Iraq

    Ahmed Alawadi

  7. College of Technical Engineering, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq

    Ahmed Alawadi

  8. College of Technical Engineering, the Islamic University of Babylon, Babylon, Iraq

    Ahmed Alawadi

  9. Anesthesia Techniques, Al–Nisour University College, Baghdad, Iraq

    Mohammed Jawad Alnajar

  10. College of Nursing, National University of Science and Technology, Nasiriyah, Dhi Qar, Iraq

    Nagat Salah Shalaby

  11. Cardiology Department, College of Medicine, Al-Ayen University, Nasiriyah, Dhi Qar, Iraq

    Adnan Taan Alkhafaji

  12. Department of Nuclear and Renewable Energy, Ural Federal University Named After the First President of Russia Boris Yeltsin, Ekaterinburg, Russia, 620002

    Abhinav Kumar

  13. Department of Medical Laboratory Technologies, Al Rafidain University College, Bagdad, Iraq

    Rasha Salam Sahib

  14. Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq

    Yasser Fakri Mustafa

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  1. Herlina Uinarni
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  2. Wesam R. Kadhum
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Uinarni, H., Kadhum, W.R., Saleh, R.O. et al. Nanoparticle-based theranostics in nuclear medicine. J Radioanal Nucl Chem 333, 1661–1672 (2024). https://doi.org/10.1007/s10967-024-09432-7

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