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Measurement of alpha-emitting therapeutic radiopharmaceutical Ra-223 dichloride injection by close/far S-D γ-spectrum method

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Abstract

To accurately measure 223Ra dichloride injection by HPGe γ spectrometry, three calibration sources, including mixed mono-energy γ nuclide, 133Ba, and 226Ra, were used to calibrate efficiency at close/far source/sample-detector (S-D) distance. The results show that the efficiency calibration at a far S-D distance can reduce the coincidence effect of the 133Ba and 223Ra simulation source, both far and close S-D are applicable to the 226Ra simulation source; Using 269.48 keV, 271.23 keV and 351.03 keV γ-ray full energy peaks for analysis, the deviation of the results between the simulation sources method and the mono-energy γ nuclide source method is less than 1%. The influence of γ-ray emission probabilities, the selection of full energy peak, and coincidence effect and other factors on the 223Ra measurement results was also studied, the γ-ray emission probabilities from different nuclear databases can cause up to 30% deviation in the measurement results.

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Authors and Affiliations

  1. National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, 230027, China

    Xianbao Gu, Ping Xu, Liusi Sheng & Yilin Hong

  2. Anhui Environmental Radiation Supervision Station, Hefei, 230071, China

    Xianbao Gu, Guobing Yu & Lixun Cheng

  3. Henan Tumor Hospital, Zhengzhou, 450003, China

    Yuan Wang

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  1. Xianbao Gu
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  2. Ping Xu
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  3. Yuan Wang
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  4. Guobing Yu
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  5. Lixun Cheng
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  7. Yilin Hong
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Correspondence to Guobing Yu.

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Gu, X., Xu, P., Wang, Y. et al. Measurement of alpha-emitting therapeutic radiopharmaceutical Ra-223 dichloride injection by close/far S-D γ-spectrum method. J Radioanal Nucl Chem 332, 1435–1443 (2023). https://doi.org/10.1007/s10967-022-08681-8

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  • DOI: https://doi.org/10.1007/s10967-022-08681-8

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