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Preparative chromatographic separation of neighboring lanthanides using amines as a pH adjusting additive for producing carrier-free 177Lu

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Abstract

This study is a preliminary experiment to examine the effect of amines as additive in eluents for separating neighboring lanthanides (Lu and Yb) for efficiently producing carrier-free 177Lu. The separation method was based on cation-exchange chromatography and the pH-adjusted eluent with NH4OH or several amines. Among the amines, methylamine exhibited a longer retention time than NH4OH, and proved to be the most effective additive for separation resolution and purification. The optimized chromatographic parameters were able to effectively separate Lu from a large amount (100 mg) of Yb on a relatively short column (15 mm × 70 mm).

Graphical abstract

The effect of pH adjusting additive on the separation of adjacent lanthanides Yb and Lu was investigated with different amines. The separation efficiency was improved by using CH3NH2 instead of NH4OH as the pH adjusting additive. These results indicate that the role of the protonated amines as a physically exchangeable cation is important for the efficient separation of the lanthanide ions adsorbed on the resin.

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Acknowledgements

This study was supported by Nuclear R&D Program, Development of Production Standardized Production Technology for Theranostic RI (57831-21).

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  1. Radioisotope Research Division, Korea Atomic Energy Research Institute, 989-111, Daedeok-daero, Yuseong-gu, Daejeon, 34057, Korea

    Aran Kim & Kanghyuk Choi

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  1. Aran Kim
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  2. Kanghyuk Choi
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Correspondence to Kanghyuk Choi.

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Kim, A., Choi, K. Preparative chromatographic separation of neighboring lanthanides using amines as a pH adjusting additive for producing carrier-free 177Lu. J Radioanal Nucl Chem 331, 1451–1457 (2022). https://doi.org/10.1007/s10967-022-08216-1

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  • DOI: https://doi.org/10.1007/s10967-022-08216-1

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