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A simple isolation of 211At using an anion-exchange spin column method

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Abstract

This study demonstrated the availability of an anion-exchange spin column method for the isolation of astatine-211 (211At) from bismuth (Bi). 211At was isolated in medium-to-excellent recovery efficiencies when loading 211At with 8M HCl (75.3–79.1%), and 8M HNO3 (35.9–54.3%). The processing time of the optimized protocol was about 40 minutes. A neutralized eluent afforded an 211At-labeled phenylalanine derivative even in the absence of oxidant (radiochemical yield: 75.4%). These results indicate the anion-exchange spin column is useful for the isolation of 211At and the following synthesis of astatinated compounds, which is the first to isolate 211At with an anion-exchange method.

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Acknowledgements

We would like to thank the staff of the Project “Medical Radioisotope Application” at the Takasaki Advanced Radiation Research Institute of QST. We are also grateful to Mr. Akihiko Shimada for his helpful support, and Mr. Koji Imai, Mr. Masashi Koka, and the staff of the TIARA for operating the AVF cyclotron. This work was supported in part by a JSPS KAKENHI 17K10459 (Sh. Watanabe).

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Authors and Affiliations

  1. Department of Radiation-Applied Biology, Takasaki Advanced Radiation Research Institute, National Institutes for Quantum and Radiological Science and Technology (QST), 1233 Watanuki, Takasaki, Gunma, 370-1292, Japan

    Shigeki Watanabe, Ichiro Sasaki, Satoshi Watanabe & Noriko S. Ishioka

  2. Division of Molecular Science, Graduate School of Science and Technology, Gunma University, 4-2 Aramaki, Maebashi, Gunma, 371-8510, Japan

    Ichiro Sasaki

  3. Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, QST, 4-9-1 Anagawa, Chiba, 263-8555, Japan

    Tatsuya Higashi

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  1. Shigeki Watanabe
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  2. Ichiro Sasaki
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  3. Satoshi Watanabe
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  4. Tatsuya Higashi
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  5. Noriko S. Ishioka
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Shigeki Watanabe, Ichiro Sasaki, and Satoshi Watanabe. Supervision and funding acquisition were performed by Tatsuya Higashi and Noriko S. Ishioka. The first draft and revised version of the manuscript were written by Shigeki Watanabe and all authors commented on all versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Shigeki Watanabe.

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Watanabe, S., Sasaki, I., Watanabe, S. et al. A simple isolation of 211At using an anion-exchange spin column method. J Radioanal Nucl Chem 326, 1399–1404 (2020). https://doi.org/10.1007/s10967-020-07422-z

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  • DOI: https://doi.org/10.1007/s10967-020-07422-z

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