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A proposal of excipients mixture for the elaboration of Na131I capsules

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Abstract

Since the use of radioiodine for thyroid therapy in the form of an oral solution has risks associated with contamination, the need to develop suitable Na131I capsules has attracted significant attention. A series of different mass combinations of excipients was prepared using ascorbic acid, sodium thiosulphate, mannitol, maltose, magnesium sulphate, lactose, dextrose, sodium phosphate, and sucrose. These compounds were tested for their volatility and oxidation profile. Two of the excipient mixtures were selected to prepare capsules due to their high stability and low volatility. The experiments performed to evaluate a new excipients mixture are described in this manuscript.

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Acknowledgements

The authors are grateful for the financial support of the Fondo Nacional de Desarrollo Científico Tecnológico y de Innovación (FONDECYT) and to the staff of Analytical Techniques Laboratory and the Radioisotope Production Plant for their contributions.

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Authors and Affiliations

  1. Facultad de Ciencias Naturales y Formales, Universidad Nacional Federico Villarreal, Lima, Peru

    Martha Alviar

  2. Planta de Producción de Radioisótopos, Instituto Peruano de Energía Nuclear (IPEN), Lima, Peru

    Jesus Miranda

  3. Laboratorio de Técnicas Analíticas, Instituto Peruano de Energía Nuclear (IPEN), Lima, Peru

    Patricia Bedregal

Authors
  1. Martha Alviar
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  2. Jesus Miranda
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  3. Patricia Bedregal
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Correspondence to Martha Alviar.

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Alviar, M., Miranda, J. & Bedregal, P. A proposal of excipients mixture for the elaboration of Na131I capsules. J Radioanal Nucl Chem 325, 857–862 (2020). https://doi.org/10.1007/s10967-020-07255-w

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  • DOI: https://doi.org/10.1007/s10967-020-07255-w

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