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Synthesis of deuterium-labeled (3R, 5S)-fluvastatin and (3S, 5R)-fluvastatin

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Abstract

In order to comprehensively understanding the metabolism process of fluvastatin, the stable isotope-labeled (3R, 5S)-fluvastatin and (3S, 5R)-fluvastatin were required. Both of (3R, 5S)-fluvastatin and (3S, 5R)-fluvastatin were synthesized via a seven steps procedure starting from aniline and [2H6] 2-bromopropane. Two versions of deuterium labeled compound revealed over 98% deuterium enrichment, using as an internal standard.

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Funding

Funding was provided by National Natural Science Foundation of China (Grant No. 41472124), PetroChina Innovation Foundation (Grant Nos. 2015D-5006-0210 and 2016D-5007-0702) and Nature Science Foundation of Hubei Province (Grant No. 2016CFB178).

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Authors and Affiliations

  1. School of Resources and Environment, Yangtze University, 1 Daxue Road, Caidian District, Wuhan, 430100, Hubei, People’s Republic of China

    Mei He

  2. School of Biochemical and Environmental Engineering, Nanjing Xiaozhuang University, 3601 Hongjing Road, Nanjing, 211171, Jiangsu, People’s Republic of China

    Jian Li

  3. School of Petroleum Engineering, Yangtze University, 1 Daxue Road, Caidian District, Wuhan, 430100, Hubei, People’s Republic of China

    Lei Tian

Authors
  1. Mei He
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  2. Jian Li
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Correspondence to Lei Tian.

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He, M., Li, J. & Tian, L. Synthesis of deuterium-labeled (3R, 5S)-fluvastatin and (3S, 5R)-fluvastatin. J Radioanal Nucl Chem 319, 263–269 (2019). https://doi.org/10.1007/s10967-018-6279-1

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  • DOI: https://doi.org/10.1007/s10967-018-6279-1

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