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Synthesis of a diastereomeric mixture of deuterium-labeled lovastatin and its acid ammonium salt

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Abstract

In this communication, a facile synthesis for (2S/2R)-[2H3]lovastatin and (2S/2R)-[2H3]lovastatin acid ammonium salt was described. The stable isotope-labeled (2S/2R)-lovastatin and its acid ammonium salt were prepared from butyric acid via several reaction steps with 11.1 and 6.3 % overall yield, respectively.

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Fig. 1
Scheme 1

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Acknowledgments

We are grateful to Mr. Zhaoyang Wang (General Manager, Dalian DTRX Chemical Ltd. Co.) for providing intermediate (5). We also like to thank Prof. Xiaohong Hou (The School of Pharmaceutical Engineering, Shenyang Pharmaceutical University) for the HPLC analysis.

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Authors and Affiliations

  1. Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China

    Dawei Liang, Shuang Li, Meihui Zhang & Jinhua Dong

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  1. Dawei Liang
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  2. Shuang Li
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  3. Meihui Zhang
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  4. Jinhua Dong
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Correspondence to Jinhua Dong.

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Liang, D., Li, S., Zhang, M. et al. Synthesis of a diastereomeric mixture of deuterium-labeled lovastatin and its acid ammonium salt. J Radioanal Nucl Chem 300, 891–894 (2014). https://doi.org/10.1007/s10967-014-2993-5

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  • DOI: https://doi.org/10.1007/s10967-014-2993-5

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