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Preparation and biodistribution of 131I-labeled graphene quantum dots

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Abstract

For the superiority of graphene quantum dots (GQDs) in bioimaging and drug delivery carrier, GQDs bring new opportunities for theranostics of diseases. In this study, GQDs were successfully prepared and labeled with 131I. The in vitro properties, biodistribution and SPECT imaging of 131I-GQDs were investigated. The uptake of 131I-GQDs at tumor sites can be clearly observed via SPECT imaging and T/B and T/M ratios increase with increasing time, which can contribute to enhanced permeability and retention (EPR) effect.

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Acknowledgements

This work was financially supported by the National Nature Science Foundation of China (NSFC-21471138, NSFC-21401176).

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Authors and Affiliations

  1. School of Physical Sciences, University of Science and Technology of China, Hefei, 230029, People’s Republic of China

    Hu Song & Shunzhong Luo

  2. Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang, 621999, People’s Republic of China

    Hu Song, Yunhan Wang, Jing Wang, Guanquan Wang, Jiaheng He, Hongyuan Wei & Shunzhong Luo

  3. First Affiliated Hospital of Southwest Medical University, Luzhou, 646000, People’s Republic of China

    Yunhan Wang & Hongyuan Wei

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  1. Hu Song
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  2. Yunhan Wang
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  3. Jing Wang
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  4. Guanquan Wang
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  5. Jiaheng He
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  7. Shunzhong Luo
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Correspondence to Shunzhong Luo.

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Song, H., Wang, Y., Wang, J. et al. Preparation and biodistribution of 131I-labeled graphene quantum dots. J Radioanal Nucl Chem 316, 685–690 (2018). https://doi.org/10.1007/s10967-018-5804-6

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  • DOI: https://doi.org/10.1007/s10967-018-5804-6

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