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Synthesis and evaluation of triphenylphosphonium conjugated 18F-labeled silica nanoparticles for PET imaging

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Abstract

Accumulation of triphenylphosphonium (TPP) is normally observed in the mitochondria from the extracellular spaces due to the high difference in plasma membrane potential of the mitochondria. In the cancer cells, the mitochondrial membrane potential gap is higher as compared to that of normal cells resulting in elevated uptake of TPP. Silica nanoparticles (SNPs) being widely developed and used for biomedical applications, in this study, we tried to modify the surface of SNPs with varying amounts of TPP to verify their possible application as a positron emission tomography (PET) agent. The studies confirmed that the high level of TPP loading on the surface of SNPs possess higher positive charge (+ 31.5 mV). Owing to this behavior of plasma membrane potential of cancerous cells the uptake of positively charged SNPs was much higher in tumor cells than that of normal cells which was confirmed by PET imaging.

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Acknowledgements

Our study was supported by the Nuclear R&D Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (2015M2A2A4A02043265 and 2016M2C2A1937989).

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Authors and Affiliations

  1. Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup, Republic of Korea

    Gun Gyun Kim, Jun Young Lee, Pyeong Seok Choi, Chirag K. Vyas, Seung Dae Yang, Min Gu Hur & Jeong Hoon Park

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  1. Gun Gyun Kim
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  2. Jun Young Lee
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  3. Pyeong Seok Choi
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  4. Chirag K. Vyas
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Correspondence to Jeong Hoon Park.

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Kim, G.G., Lee, J.Y., Choi, P.S. et al. Synthesis and evaluation of triphenylphosphonium conjugated 18F-labeled silica nanoparticles for PET imaging. J Radioanal Nucl Chem 316, 1099–1106 (2018). https://doi.org/10.1007/s10967-018-5763-y

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  • DOI: https://doi.org/10.1007/s10967-018-5763-y

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