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69mZn-containing radiopharmaceuticals: a novel approach to molecular design

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Abstract

69mZn was produced and separated for medical applications. Possibilities and perspectives for production of radiopharmaceuticals based on 69mZn containing derivatives of thiazine, thiazoline and thiourea are considered. Each one of the latters is a zinc chelator and a nitric oxide synthase (NOS) effector at the same time. Cytotoxic effect of NOS activator and NOS inhibitors are shown in experiments with HL-60, K-562 and MOLT-4 cell lines and in bone marrow cells of the acute B-lymphoblastic leukemia patients. Some of those compounds are worthy to get selected for further application as radiopharmaceuticals including their antitumor speciements.

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Acknowledgments

This study was supported by grant of RFBR 16-08-00139.

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Authors and Affiliations

  1. Department of Chemical, Lomonosov Moscow State University, Leninskie Gory, 1, Bd.3, Moscow, 119992, Russia

    Marina A. Orlova, Tatiana P. Trofimova, Ramiz A. Aliev, Alexey P. Orlov & Stepan N. Kalmykov

  2. Department of Biochemistry and Pharmacology, Rogachev Federal Clinical Center of Pediatric Hematology, Oncology and Immunology, Samora Mashel St, 1, Moscow, 117997, Russia

    Marina A. Orlova, Tatiana P. Trofimova & Sergey V. Nikulin

  3. National Research Center “Kurchatov Institute” Acad., Kurchatov Sq., 1, Moscow, 123098, Russia

    Ramiz A. Aliev & Stepan N. Kalmykov

  4. Department of Organic Synthesis, Institute of Physiological Active Compounds RAS, North Pass., 1, Chernogolovka, 142432, Russia

    Alexey N. Proshin

Authors
  1. Marina A. Orlova
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  2. Tatiana P. Trofimova
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  3. Ramiz A. Aliev
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  4. Alexey P. Orlov
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  5. Sergey V. Nikulin
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Correspondence to Marina A. Orlova.

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Orlova, M.A., Trofimova, T.P., Aliev, R.A. et al. 69mZn-containing radiopharmaceuticals: a novel approach to molecular design. J Radioanal Nucl Chem 311, 1177–1183 (2017). https://doi.org/10.1007/s10967-016-5076-y

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  • DOI: https://doi.org/10.1007/s10967-016-5076-y

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