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Primary evaluation of a nickel-chlorophyll derivative as a multimodality agent for tumor imaging and photodynamic therapy

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Abstract

In this study, the biological potential of a nickel chlorophyll derivative (Ni-PH-A) as a multimodal agent for tumor imaging and photodynamic therapy (PDT) was investigated. Optimum conditions of labeling with 131I were investigated and determined as pH 10 and 1 mg amount of iodogen. Biodistribution results of 131I labeled Ni-PH-A in female rats indicated that radiolabeled Ni-PH-A maximum uptake in the liver, spleen and ovary was observed at 30 min. Intercellular uptake and PDT efficacy of Ni-PH-A were better in MDAH-2774 (human ovarian endometrioid adenocarcinoma) than in MCF-7 (human breast adenocarcinoma) cells. Ni-PH-A might be a promising multimodal agent for lung, ovary and liver tumor imaging and PDT.

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Acknowledgments

The authors gratefully acknowledge financial support by The Scientific and Technological Research Council of Turkey, TUBITAK (Grant No.: 112T565) and Department of Scientific Projects at Ege University, Izmir, Turkey (12 NBE008).

Conflict of interest

The authors declared no declaration of interest.

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Authors and Affiliations

  1. Department of Nuclear Applications, Institute of Nuclear Science, Ege University, 35100, Bornova, Izmir, Turkey

    Ozge Er & Fatma Yurt Lambrecht

  2. Advanced Technology Research & Application Center, Mersin University, Ciftlikkoy Campus, 33343, Yenisehir, Mersin, Turkey

    Kasim Ocakoglu

  3. Department of Energy Systems Engineering, Faculty of Tarsus Technology, Mersin University, 33480, Tarsus, Mersin, Turkey

    Kasim Ocakoglu

  4. Department of Medical Biology, Faculty of Medicine, Ege University, 35100, Bornova, Izmir, Turkey

    Cagla Kayabasi & Cumhur Gunduz

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  1. Ozge Er
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  2. Fatma Yurt Lambrecht
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  4. Cagla Kayabasi
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Correspondence to Fatma Yurt Lambrecht.

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Er, O., Lambrecht, F.Y., Ocakoglu, K. et al. Primary evaluation of a nickel-chlorophyll derivative as a multimodality agent for tumor imaging and photodynamic therapy. J Radioanal Nucl Chem 306, 155–163 (2015). https://doi.org/10.1007/s10967-015-4081-x

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  • DOI: https://doi.org/10.1007/s10967-015-4081-x

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