Skip to main content
SpringerLink
Log in

Distribution of 131I-labeled recombinant human erythropoietin in maternal and fetal organs following intravenous administration in pregnant rats

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

The aim of the present study was to demonstrate the possible transplacental transmission of 131I labeled recombinant human erythropoietin (131I-rh-EPO) in pregnant rats and its distribution through maternal and fetal organs. Six Wistar Albino Rats in their pregnancy of 18 days were used 131I labeled recombinant human erythropoietin (specific activity = 2.4 μCi/IU) was injected into the tail vein of rats. After 30 minutes labeled erythropoietin infusion maternal stomach, kidney, lung, liver, brain and heart as well as fetus were removed. Then, the same organs were removed from each fetus. Measuring weight of maternal and fetal organs as well as placenta were followed by radioactivity count via Cd(Te) detector. 131I labeled recombinant human erythropoietin was found to be able to pass rat placenta and its distribution order in fetal organs was similar to those of maternal organs. Besides, as measurements were performed closer to cornu uteri, uptakes were decreasing in every fetus and its corresponding placenta.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. W. Fisher, Exp. Biol. Med., 228 (2003) 1.

    CAS  Google Scholar 

  2. Z. Z. Chong, J. Q. Kang, K. Maiese, Curr. Drugs Targets-Cardiovasc. Haematol. Disord., 3 (2003) 141.

    Article  CAS  Google Scholar 

  3. H. Kinoshita, N. Ohishi, A. Okazaki, Arzneimittelforschung, 4 (1991) 568.

    Google Scholar 

  4. M. J. Koury, M. C. Bondurant, S. E. Graber, S. T. Sawyer, J. Clin. Invest., 82 (1988) 154.

    Article  CAS  Google Scholar 

  5. J. A. Widness, S. T. Sawyer, R. L. Schmidt, D. H. Chestnut, J. Dev. Physiol., 15 (1991) 139.

    CAS  Google Scholar 

  6. J. A. Widness, T. A. Malone, R. A. Mufson, Pediatr. Res., 25 (1989) 649.

    Article  CAS  Google Scholar 

  7. E. D. Zanjani, J. S. Pixley, N. Slotnick, F. R. Mackintosh, D. Ekhterae, G. Clemons, Pathobiology, 61 (1993) 211.

    Article  CAS  Google Scholar 

  8. H. Kinoshita, N. Ohishi, M. Kato, S. Tokura, A. Okazaki, Arzneim-Forsch/Drug Res., 42 (1992) 174.

    CAS  Google Scholar 

  9. E. C. Greene, Anatomy of the Rat, Circulatory System, 1st ed., Hafner Publishing Co., New York, 1963, p. 204.

    Google Scholar 

  10. J. A. Widness, R. L. Schmidt, S. T. Sawyer, J. Perinat. Med., 23 (1995) 61.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Animal Research Center, Dokuz Eylul University School of Medicine, Izmir, Turkey

    O. Yilmaz

  2. Department of Nuclear Applications, Ege University Institute of Nuclear Sciences, Izmir, Turkey

    F. Y. Lambrecht & K. Durkan

  3. Department of Anesthesiology and Reanimation, Dokuz Eylul University School of Medicine, Izmir, Turkey

    N. Gokmen

  4. Department of Neurosurgery, Dokuz Eylul University School of Medicine, Izmir, Turkey

    S. Erbayraktar

Authors
  1. O. Yilmaz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Y. Lambrecht
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Gokmen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Erbayraktar
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. Durkan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yilmaz, O., Lambrecht, F.Y., Gokmen, N. et al. Distribution of 131I-labeled recombinant human erythropoietin in maternal and fetal organs following intravenous administration in pregnant rats. J Radioanal Nucl Chem 273, 311–313 (2007). https://doi.org/10.1007/s10967-007-6859-y

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10967-007-6859-y

Keywords

Search

Navigation