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Elemental analysis of biological tissues of animal models in muscular dystrophies investigation

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Abstract

Element concentrations in biological tissues of Dmdmdx/J and C57BL/6 J mice strains were determined using the neutron activation analysis technique. Samples of whole blood, bones and organs (heart and muscle) of these strains were irradiated in the IEA–R1 nuclear reactor at IPEN-CNEN/SP (Brazil). To perform this investigation biological samples of two-month-old adult females (n = 10) and males (n = 9) for Dmdmdx/J (dystrophic mice), and males (n = 12) for C57BL/6 J (control group), originally obtained from the Jackson Laboratory (Maine, USA) and further inbred at IPEN–CNEN/SP (São Paulo, Brazil), were used. A significant change was observed in the analysis of the heart of dystrophic mice suggesting that this dysfunction affects severely the heart muscle. These data may, in the future, contribute to the healthcare area, in veterinary medicine and in the pharmaceutical industry allowing the evaluation of the best procedures in diagnosis, treatment and investigations of neuromuscular diseases (muscular dystrophy) of patients through the use of animal models.

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Acknowledgments

The authors would like to thanks, Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and Modern Trends in Activation Analysis–13 (MTAA-13) for the financial support.

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Authors and Affiliations

  1. Instituto de Pesquisas Energéticas e Nucleares - IPEN/CNEN-SP, Av. Prof. Lineu Prestes, 2242 - Cidade Universitária, São Paulo, SP, 05508-000, Brazil

    Sabrina Metairon, Cibele B. Zamboni & Miriam F. Suzuki

  2. Centro de Estudos do Genoma Humano, Instituto de Biociências, Rua do Matão, Travessa 13, 106 - Cidade Universitária, São Paulo, SP, 05508-090, Brazil

    Carlos R. Bueno Jr.

  3. Instituto Butantan, Av. Vital Brasil 1500 - Butantã, São Paulo, SP, 05503-900, Brazil

    Osvaldo A. Sant’Anna

Authors
  1. Sabrina Metairon
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  2. Cibele B. Zamboni
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  3. Miriam F. Suzuki
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  4. Carlos R. Bueno Jr.
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  5. Osvaldo A. Sant’Anna
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Corresponding author

Correspondence to Miriam F. Suzuki.

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Metairon, S., Zamboni, C.B., Suzuki, M.F. et al. Elemental analysis of biological tissues of animal models in muscular dystrophies investigation. J Radioanal Nucl Chem 291, 373–378 (2012). https://doi.org/10.1007/s10967-011-1275-8

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  • DOI: https://doi.org/10.1007/s10967-011-1275-8

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