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Quantitative evaluation of blood elements by neutron activation analysis in mice immunized with Bothrops snake venoms

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Abstract

Mice genetically selected for high antibody responsiveness (HIII) were immunized against different Bothrops species snake venoms from distinct region of Brazil. The Neutron Activation Analysis technique was used to evaluate the whole blood concentrations of elements of clinical relevance [Ca, Cl, K, Mg and Na] in order to establish a potential correlation between antibody response and blood constituents after Bothrops venom administration for clinical screening of envenomed patients.

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Acknowledgments

The authors thank the financial support of FAPESP, CNPq - INCTTOX and CENP. O. A. Sant’Anna and D. V. Tambourgi are researchers of CNPq.

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Authors and Affiliations

  1. Instituto de Pesquisas Energéticas e Nucleares, IPEN–CNEN/SP, Av. Professor Lineu Prestes, 2242, São Paulo, SP, 05508-000, Brazil

    C. B. Zamboni, S. Metairon & M. F. Suzuki

  2. Instituto Butantan, Av. Vital Brazil, 1500, São Paulo, SP, 05503-900, Brazil

    M. F. Furtado, O. A. Sant’Anna & D. V. Tambourgi

Authors
  1. C. B. Zamboni
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  2. S. Metairon
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  3. M. F. Suzuki
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  4. M. F. Furtado
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  5. O. A. Sant’Anna
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  6. D. V. Tambourgi
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Corresponding author

Correspondence to M. F. Suzuki.

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Zamboni, C.B., Metairon, S., Suzuki, M.F. et al. Quantitative evaluation of blood elements by neutron activation analysis in mice immunized with Bothrops snake venoms. J Radioanal Nucl Chem 282, 37–39 (2009). https://doi.org/10.1007/s10967-009-0275-4

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  • DOI: https://doi.org/10.1007/s10967-009-0275-4

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