Abstract
The interference of excessive bromide intake with iodine metabolism in the rat was studied using 82Br and 131I radionuclides. Mainly lactating rat dams and their pups were used, in addition to adult male rats, in the present studies. Particularly, the influence of high bromide intake in lactating rat dams on the transfer of iodine and bromide to suckling young through breast milk was evaluated. The induction of hypothyroid status in the pups by high bromide intake in the mothers was proved unambiguously. Excessive bromide in lactating rat dams caused a marked decrease in plasma levels of thyroid hormones both, in the mothers and in their sucklings. The effects of an enhanced bromide intake on the thyroid function in relation to iodine status in the animals were also followed. Marked goitrogenic and thyrotoxic effects of excessive bromide in adult rats were significantly enhanced under the conditions of simultaneous iodine deficiency in the experimental animals.
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This study was supported by the Academy of Sciences of the Czech Republic (Research Project No. AV0Z50110509), by the Ministry of Education of the Czech Republic (Research Project No. MSM0021622413) and by the Czech Science Foundation (GA CR grant no. 304/08/0256).
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Pavelka, S. Use of 82Br and 131I radionuclides in studies of goitrogenic effects of exogenous bromide. J Radioanal Nucl Chem 291, 379–383 (2012). https://doi.org/10.1007/s10967-011-1190-z
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DOI: https://doi.org/10.1007/s10967-011-1190-z