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Study of dosimetric properties of acetylsalicylic acid in pharmaceutical preparations by EPR spectroscopy

  • Radiation Chemistry
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Abstract

Electron paramagnetic resonance (EPR) was used to investigate the dosimetric properties of two pharmaceutical preparations containing acetylsalicylic acid, Aspirin® and Cafiaspirin®. The EPR spectra of the irradiated samples were found to have an asymmetric absorption characterized by a major resonance at g = 2.0033. Dose response was investigated between dose ranges of 2 to 95 kGy for 60Co-gamma rays. Fading characteristics and dependence on temperature irradiation were also studied. We suggest that commercial Aspirin® and Cafiaspirin® tablets can be used as dosimeters in the case of a short accident.

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Authors and Affiliations

  1. Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, UNAM, A.P. 70-543, Ciudad Universitaria, Del. Coyoacán, 04510, México D.F, Mexico

    J. M. Juárez-Calderón, A. Negrón-Mendoza & S. Ramos-Bernal

  2. Instituto de Química, Universidad Nacional Autónoma de México, UNAM, Mexico, Mexico

    V. Gómez-Vidales

Authors
  1. J. M. Juárez-Calderón
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  2. A. Negrón-Mendoza
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  3. V. Gómez-Vidales
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  4. S. Ramos-Bernal
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Corresponding author

Correspondence to A. Negrón-Mendoza.

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Juárez-Calderón, J.M., Negrón-Mendoza, A., Gómez-Vidales, V. et al. Study of dosimetric properties of acetylsalicylic acid in pharmaceutical preparations by EPR spectroscopy. J Radioanal Nucl Chem 280, 245–249 (2009). https://doi.org/10.1007/s10967-009-0506-8

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  • DOI: https://doi.org/10.1007/s10967-009-0506-8

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