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Dosimetric Identification of Gamma-Irradiated Progesterone and Propranolol Hydrochloride by Electron Paramagnetic Resonance Spectroscopy

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Abstract

In this study, radiation sensitivities of progesterone and propranolol hydrochloride samples irradiated with gamma in the 0–25 kGy dose range, which are widely used in medicine, were investigated by electron paramagnetic (EPR) resonance spectroscopy. Since the microwave saturation behavior of free radicals contributing to the spectra may be different, curves of signal intensities of the irradiated samples were obtained in the range of 0–15 mW depending on the microwave power. By using irradiated samples at dose values of 1, 5, 10, 15, 20 and 25 kGy, dose–response curves of the samples were obtained and the most appropriate mathematical functions and correlation coefficients were calculated. In addition, the extinction curves of the signal intensities of the samples were determined to test the stability of the free radicals formed in the irradiated samples at room temperature.

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The authors confirm that the datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Science, Faculty of Education, Dicle University, 21280, Diyarbakir, Turkey

    Kerem Sütçü

  2. Department of Oncology, Faculty of Medicine, Dicle University, 21280, Diyarbakir, Turkey

    Yunus Emre Osmanoğlu

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  1. Kerem Sütçü
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  2. Yunus Emre Osmanoğlu
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Contributions

KS: conceptualization, methodology, software, validation, formal analysis, investigation, data curation, writing—original draft, writing—review and editing, visualization, supervision. YEO: conceptualization, methodology, resources, data curation, writing—original draft, writing—review & editing, visualization, and supervision.

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Correspondence to Kerem Sütçü.

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Sütçü, K., Osmanoğlu, Y.E. Dosimetric Identification of Gamma-Irradiated Progesterone and Propranolol Hydrochloride by Electron Paramagnetic Resonance Spectroscopy. Appl Magn Reson 54, 833–847 (2023). https://doi.org/10.1007/s00723-023-01566-3

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