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Synthesis of a bis-(N-butyl-dithiocarbamato)-nitrido 99mTc complex: A potential new brain imaging agent

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Abstract

The bis(N-butyl dithiocarbamato) nitrido 99mTc complex [99mTcN(BDTC)2] (BDTC: N-butyl dithiocarbamato) has been synthesized through a ligand-exchange reaction. The two-step procedure consisted of an initial reaction of 99mTcO4 − with succinic dihydrazide (SDH) in the presence of stannous chloride as reducing agent and propylenediamine tetraacetic acid (PDTA) as complexing agent, and subsequent addition of sodium salt of N-butyl dithiocarbamate. The radiochemical purity of the complex was over 90%, as measured by thin layer chromatography. No decomposition of the complex at room temperature was observed over a period of 6 hours. Its partition coefficient indicated that it was a lipophilic complex. The electrophoresis results showed the complex was neutral. Biodistribution in mice showed that the complex accumulated in the brain with high uptake. The brain/blood ratio was 1.58, 1.67 and 1.20 at 5, 30 and 60-minute post-injection, respectively, suggesting this compound would be a potential cerebral imaging agent.

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Authors and Affiliations

  1. Key Laboratory of Radiopharmaceuticals, Ministry of Education; Department of Chemistry, Beijing Normal University, Beijing, 100875, P.R. China

    JunBo Zhang, XueBin Wang & ChunJun Tian

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  1. JunBo Zhang
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  2. XueBin Wang
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  3. ChunJun Tian
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Zhang, J., Wang, X. & Tian, C. Synthesis of a bis-(N-butyl-dithiocarbamato)-nitrido 99mTc complex: A potential new brain imaging agent. J Radioanal Nucl Chem 273, 15–17 (2007). https://doi.org/10.1007/s10967-007-0703-2

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  • DOI: https://doi.org/10.1007/s10967-007-0703-2

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