Abstract
We report here a facile synthesis of racemic carboxyl 14C labeled phenylglycine. Toluene was brominated in presence of manganese dioxide to give benzyl bromide (>98%), which on cyanation with K14CN followed by acid hydrolysis under microwave enhanced conditions gave [1-14C]-2-phenyl ethanoic acid. The latter on α-bromination followed by amination with liquid ammonia furnished a racemic mixture of the title compound with a yield >90% with respect to K14CN. The racemic mixture was resolved using L(+) tartarate to give D and L phenylglycine.
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Ravi, S., Mathew, K.M., Unny, V.K.P. et al. A facile synthesis of racemic carboxyl 14C-labeled phenylglycine under microwave irradiation. J Radioanal Nucl Chem 274, 61–62 (2007). https://doi.org/10.1007/s10967-006-6900-6
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DOI: https://doi.org/10.1007/s10967-006-6900-6