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Characterization of drug-loaded alginate-chitosan polyelectrolyte nanoparticles synthesized by microfluidics

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Abstract

In this study, the microfluidic approach (MF) and the bulk mixing method (BM) were utilized to synthesize 5-fluorouracil (5-FU)-loaded alginate-chitosan (Alg-CS) polyelectrolyte-based nanoparticles (NPs). Characterization studies revealed that MF NPs obtained a smaller mean diameter (~ 115 nm), narrower polydispersity index (0.14), and also a higher zeta potential (-38 mV) compared with BM NPs. Furthermore, drug encapsulation efficiency (EE) and drug loading capacity (LC) were both higher for MF NPs (%84 and %11, respectively). Moreover, convenient compatibility between 5-FU and Alg-CS was evidenced via fourier transform infrared spectroscopy (FTIR) test. In vitro release studies coupled with its kinetics revealed that drug release from MF NPs not only experienced a lower burst release (%4 after 30 min) but also a more controlled release (%29 after 8 h), and in turn, its release behavior followed the Higuchi model at different pHs. Eventually, due to the desirable properties of MF NPs, they can be considered a reliable drug delivery system for the controlled release of 5-FU.

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Data availability

The raw data required to reproduce these findings are available from the corresponding author upon request.

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Acknowledgements

The authors would like to thank the Research Council of University of Tehran for the financial support in this work.

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  1. Nano-Biopolymers Research Laboratory, School of Chemical Engineering, College of Engineering, University of Tehran, P. O. Box, Tehran, 11155-4563, Iran

    Mohammad Hossein Zamani, Alireza Khatibi, Beeta Tavana, Payam Zahedi & Shayesteh Aghamohammadi

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Contributions

Mohammad Hossein Zamani: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing-original draft. Alireza Khatibi: Formal analysis, Data curation, Investigation, Methodology, Writing-review & editing. Beeta Tavana: Formal analysis, Data curation, Investigation, Methodology, Writing-review & editing. Payam Zahedi: Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing-review & editing. Shayesteh Aghamohammadi: Investigation, Methodology, Writing-review & editing.

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Correspondence to Payam Zahedi.

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Zamani, M.H., Khatibi, A., Tavana, B. et al. Characterization of drug-loaded alginate-chitosan polyelectrolyte nanoparticles synthesized by microfluidics. J Polym Res 30, 86 (2023). https://doi.org/10.1007/s10965-023-03468-1

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