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A novel polyamidoamine dendrimer based nano-carrier for oral delivery of imatinib

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Abstract

Designing and developing efficient and non-toxic drug delivery systems is an exciting subject in pharmacology and cancer therapy. In this study, we have developed a nano-carrier based on the third generation of polyamidoamine (PAMAM-G3) dendrimer, grafted with polyethylene glycol (PEG 4000) and folic acid (FA) for oral delivery of Imatinib (IM) with sustained release. The synthesized drug carrier and the manufactured nano-complexes (two different amounts of IM encapsulated by the drug carrier) were characterized using FTIR and 1HNMR spectroscopy, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), dynamic light scattering (DLS), and zeta potential analysis. The SEM images showed a typical smooth brittle structure for nano-complexes and, DSC thermograms confirmed the purity and integrity of both formulations. The average size of nano-complexes using DLS analysis was estimated to be around 100 nm with a zeta potential of + 0.2 mV. The drug loading efficiency and the drug release of nano-complexes were also studied in-vitro at pH 7.4 using UV–Vis spectroscopy. The manufactured nano carrier showed efficient entrapment of IM drug, and a sustained release was observed for nano-complexes in physiological conditions. Both formulations were effective against the human colorectal cancer cell line (SW480) and the human lung cancer cell line (A549) in the in-vitro cellular growth inhibition method. The best result was acquired against the cell line SW480 with the IC50 value of 38.88 ± 0.13 (μg.mL−1).

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Authors and Affiliations

  1. Department of Chemistry, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran

    Shabnam Fakhari, Mina Jamzad, Azita Nouri, Samira Arab-Salmanabadi & Foujan Falaki

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  1. Shabnam Fakhari
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Fakhari, S., Jamzad, M., Nouri, A. et al. A novel polyamidoamine dendrimer based nano-carrier for oral delivery of imatinib. J Polym Res 29, 523 (2022). https://doi.org/10.1007/s10965-022-03359-x

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