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Structural, thermal, morphological and antibacterial activities of hybrid bio-nanocomposite Chitosan/Au/Bi2O3 for biomedical applications

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Abstract

Hybrid bio-nanocomposite of chitosan/Au/Bi2O3 films are prepared using nontoxic and low cost laser ablation method. The prepared nanocomposites are used to be applied as a wound healing materials. XRD and ATR-FTIR techniques are used to confirm the interaction and computability between the nanomaterials and chitosan polymer. The change in surface morphology is investigated used FESEM and the addition of both Au and Bi2O3 increase the surface roughness that is useful in wound dressing application. The thermal stability is also studied to investigate the thermal behavior of the films and found that addition of Bi2O3 NPs serves as a heat and mass insulator during thermal decomposition, which enhance the thermal stability of chitosan/Au NPs. The antibacterial activity of the synthesized chitosan/Au/Bi2O3 bio-nanocomposites toward gram-positive gram-negative bacteria was studied.

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References

  1. Li T, Sun M, Wu S (2022) State-of-the-Art Review of Electrospun Gelatin-Based Nanofiber Dressings for Wound Healing Applications. Nanomaterials 12(5):784

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Li X, Fan M, Huang Q, Zhao S, Xiong S, Yin T, Zhang B (2022) Effect of micro- and nano-starch on the gel properties, microstructure and water mobility of myofibrillar protein from grass carp. Food Chem 366

  3. Wang Y, Li C, Zhang Y, Yang M, Li B, Dong L, Wang J (2018) Processing characteristics of vegetable oil-based nanofluid MQL for grinding different workpiece materials. Int J Precision Eng Manufacturing-Green Technol 5:327–339

    Article  CAS  Google Scholar 

  4. Gao T, Li C, Zhang Y, Yang M, Jia D, Jin T, Hou Y, Li R (2019) Dispersing mechanism and tribological performance of vegetable oil-based CNT nanofluids with different surfactants. Tribol Int 131:51–63

    Article  CAS  Google Scholar 

  5. Zhang N, Jiao B, Ye Y, Kong Y, Du X, Liu R, Jia K (2022) Embedded cooling method with configurability and replaceability for multi-chip electronic devices. Energy Convers Manag 253

  6. Wang M, Jiang C, Zhang S, Song X, Tang Y, Cheng H (2018) Reversible calcium alloying enables a practical room-temperature rechargeable calcium-ion battery with a high discharge voltage. Nat Chem 10(6):667–672

    Article  CAS  PubMed  Google Scholar 

  7. Mu S, Liu Q, Kidkhunthod P, Zhou X, Wang W, Tang Y (2020) Molecular grafting towards high-fraction active nanodots implanted in N-doped carbon for sodium dual-ion batteries. Nat sci rev 8(7)

  8. Zhang X, Tang Y, Zhang F, Lee C (2016) A Novel Aluminum-Graphite Dual-Ion Battery. Adv Energy Mater 6(11):1502588

    Article  CAS  Google Scholar 

  9. Zhao C, Xi M, Huo J, He C, Fu L (2022) Electro-reduction of N2 on nanostructured materials and the design strategies of advanced catalysts based on descriptors. Maters Today Phys

  10. Yang Y, Wang Y, Zheng C, Lin H, Xu R, Zhu H, Bao L, Xu X (2022) Lanthanum carbonate grafted ZSM-5 for superior phosphate uptake: Investigation of the growth and adsorption mechanism. Chem eng j (Lausanne, Switzerland : 1996), 430:133166

  11. Zhao C, Xi M, Huo J, He C, Fu L (2022) Computational Design of BC 3N 2 Based Single Atom Catalyst for Dramatic Activation of Inert CO 2 and CH 4 Gases into CH 3COOH with Ultralow CH 4 Dissociation Barrier. Chinese Chem Lett

  12. Mahyuddin HS, Roshidi MAH, Ferdosh S, Noh AL (2020) Antibacterial Activity Of Compounds From Azolla Pinnata Extracted Using Soxhlet And Supercritical Fluid (Sfe) Methods. Sci Heritage J 4(1):09–12

    Article  Google Scholar 

  13. Jaffar MZAM, Zailan AN (2021) Antimicrobial Resistance (AMR)-Forecast For 30 Countries in Europe. Sci Heritage J 5(2):44–48

    Article  Google Scholar 

  14. Yang M, Li C, Zhang Y, Jia D, Zhang X, Hou Y, Li R, Wang J (2017) Maximum undeformed equivalent chip thickness for ductile-brittle transition of zirconia ceramics under different lubrication conditions. Int J Mach Tools Manuf 122:55–65

    Article  Google Scholar 

  15. Guo S, Li C, Zhang Y, Wang Y, Li B, Yang M, Zhang X, Liu G (2017) Experimental evaluation of the lubrication performance of mixtures of castor oil with other vegetable oils in MQL grinding of nickel-based alloy. J Clean Prod 140:1060–1076

    Article  CAS  Google Scholar 

  16. Zhang J, Li C, Zhang Y, Yang M, Jia D, Liu G, Hou Y, Li R, Zhang N, Wu Q (2018) Experimental assessment of an environmentally friendly grinding process using nanofluid minimum quantity lubrication with cryogenic air. J Clean Prod 193:236–248

    Article  CAS  Google Scholar 

  17. Sun D, Huo J, Chen H, Dong Z, Ren R (2022) Experimental study of fretting fatigue in dovetail assembly considering temperature effect based on damage mechanics method. Eng Fail Anal 131:105812

    Article  Google Scholar 

  18. Ye Y, Jiao B, Kong Y, Liu R, Du X, Jia K, Chen D (2022) Experimental investigations on the thermal superposition effect of multiple hotspots for embedded microfluidic cooling. Appl Therm Eng 202:117849

    Article  CAS  Google Scholar 

  19. Periasamy AP, Yang S, Chen SM (2011) Preparation and characterization of bismuth oxide nanoparticles-multiwalled carbon nanotube composite for the development of horseradish peroxidase based H2O2 biosensor. Talanta 87:15–23

    Article  CAS  PubMed  Google Scholar 

  20. Nidhin M, Indumathy R, Sreeram KJ, Nair BU (2008) Synthesis of iron oxide nanoparticles of narrow size distribution on polysaccharide templates. Bull Mater Sci 31(1):93–96

    Article  CAS  Google Scholar 

  21. Li X, Robinson SM, Gupta A, Saha K, Jiang Z, Moyano DF, Sahar A, Riley MA, Rotello VM (2014) Functional gold nanoparticles as potent antimicrobial agents against multi-drug-resistant bacteria. ACS Nano 8(10):10682–10686

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Su C, Huang K, Li HH, Lu YG, Zheng DL (2020) Antibacterial properties of functionalized gold nanoparticles and their application in oral biology. J Nanomaters‏

  23. Lu H, Wei T, Lou H, Shu X, Chen Q (2021) A Critical Review on Communication Mechanism within Plant-Endophytic Fungi Interactions to Cope with Biotic and Abiotic Stresses. Journal of fungi (Basel) 7(9):719

    Article  CAS  Google Scholar 

  24. Abdullahi A, Bhattacharya S, Li C, Xiao Y, Wang Y (2022) Long term effect of operating loads on large monopile-supported offshore wind turbines in sand. Ocean Eng 245:110404

    Article  Google Scholar 

  25. Li BK, Li CH, Zhang YB et al (2016) Grinding temperature and energy ratio coefficient in MQL grinding of high-temperature nickel-base alloy by using different vegetable oils as base oil. Chin J Aeronaut 29(4):1084–1095

    Article  Google Scholar 

  26. Janardhanan SK, Ramasamy I, Nair BU (2008) Synthesis of iron oxide nanoparticles using chitosan and starch templates. Transition Met Chem 33(1):127–131

    Article  CAS  Google Scholar 

  27. Agnihotri SA, Mallikarjuna NN, Aminabhavi TM (2004) Recent advances on chitosan-based micro-and nanoparticles in drug delivery. J Control Release 100(1):5–28

    Article  CAS  PubMed  Google Scholar 

  28. Li LH, Deng JC, Deng HR, Liu ZL, Xin L (2010) Synthesis and characterization of chitosan/ZnO nanoparticle composite membranes. Carbohyd Res 345(8):994–998

    Article  CAS  Google Scholar 

  29. Sunil D (2013) Recennt advances on Chitosan-Metal Oxide Nanoparticles and their biological Application. In Materials Science Forum (Vol. 754, pp. 99–108). Trans Tech Publications Ltd‏

  30. Ashraf S, Pelaz B, Pino PD, Carril M, Escudero A, Parak WJ, Soliman MG, Zhang Q, Carrillo-Carrion C (2016) Gold-based nanomaterials for applications in nanomedicine. Light-Responsive Nanostructured Syst App Nanomed 169–202‏

  31. Wang K, Wang H, Pan S, Fu C, Chang Y, Li H, Yang X, Qi Z (2020) Evaluation of new film based on chitosan/gold nanocomposites on antibacterial property and wound-healing efficacy. Adv Maters Sci Eng 2020‏

  32. Lu B, Ye H, Shang S, Xiong Q, Yu K, Li Q, Xiao Y, Dai F, Lan G (2018) Novel wound dressing with chitosan gold nanoparticles capped with a small molecule for effective treatment of multiantibiotic-resistant bacterial infections. Nanotechnology 29(42):425603

    Article  PubMed  CAS  Google Scholar 

  33. Li Q, Lu F, Zhou G, Yu K, Lu B, Xiao Y, Dai F, Wu D, Lan G (2017) Silver inlaid with gold nanoparticle/chitosan wound dressing enhances antibacterial activity and porosity, and promotes wound healing. Biomacromol 18(11):3766–3775

    Article  CAS  Google Scholar 

  34. Al-Musawi S, Albukhaty S, Al-Karagoly H, Sulaiman GM, Alwahibi MS, Dewir YH, Soliman DA, Rizwana H (2020) Antibacterial activity of honey/chitosan nanofibers loaded with capsaicin and gold nanoparticles for wound dressing. Molecules 25(20):4770

    Article  CAS  PubMed Central  Google Scholar 

  35. Geoffrion LD, Medina-Cruz D, Kusper M, Elsaidi S, Watanabe F, Parajuli P, Ponce A, Hoang TB, Brintlinger T, Webster TJ, Guisbiers G (2021) Bi2O3 nano-flakes as a cost-effective antibacterial agent. Nanoscale Adv‏

  36. Ding LL, Zhao Q, Zhu JL, Fan ZJ, Liu B (2016) The preparation and property research of bismuth oxide nanospheres. In International Conference on Materials Chemistry and Environmental Protection 2015 (pp. 17–20). Atlantis Press

  37. Ahamed M, Akhtar MJ, Khan MM, Alaizeri ZM, Alhadlaq H (2021) Facile Synthesis of Zn-Doped Bi2O3 Nanoparticles and Their Selective Cytotoxicity toward Cancer Cells. ACS Omega 6(27):17353–17361

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Ali AK, Raouf DN (2011) Preparation of silver nanoparticles by pulsed laser ablation in liquid medium. J Eng Technol 29(15):3058–3066

    Google Scholar 

  39. Jassim AM, Farhan SA, Salman JA, Khalaf KJ, Al Marjani MF, Mohammed MT (2015) Study the antibacterial effect of bismuth oxide and tellurium nanoparticles. Int J Chem Biomolecular Sci 1(3):81–84

    CAS  Google Scholar 

  40. Tommalieh MJ, Ismail AM, Awwad NS, Ibrahium HA, Youssef MA, Menazea AA (2020) Investigation of electrical conductivity of gold nanoparticles scattered in polyvinylidene fluoride/polyvinyl chloride via laser ablation for electrical applications. J Electron Mater 49(12):7603–7608

    Article  CAS  Google Scholar 

  41. Barry M, Ding B, Jung Y, Reddy BVK, Phuoc TX, Chyu MK (2014) Pulsed nanosecond laser ablation of gold in deionized water and aqueous chitosan solution. Opt Lasers Eng 55:59–68

    Article  Google Scholar 

  42. Menazea AA, Ismail AM, Awwad NS, Ibrahium HA (2020) Physical characterization and antibacterial activity of PVA/Chitosan matrix doped by selenium nanoparticles prepared via one-pot laser ablation route. J Market Res 9(5):9598–9606

    CAS  Google Scholar 

  43. Ahmed MK, Mansour SF, Al-Wafi R, Menazea AA (2020) Composition and design of nanofibrous scaffolds of Mg/Se-hydroxyapatite/graphene oxide@ ε-polycaprolactone for wound healing applications. J Market Res 9(4):7472–7485

    CAS  Google Scholar 

  44. Menazea AA, Mahmoud KH, Abdel-Rahim FM (2021) Tailoring modifications in the structural, optical, and electrical conductivity properties of poly vinyl pyrrolidone/chitosan doped with vanadium pentoxide nanoparticles using laser ablation technique. Appl Phys A 127(11):1–9

    Article  CAS  Google Scholar 

  45. Abdelghany AM, Menazea AA, Ismail AM (2019) Synthesis, characterization and antimicrobial activity of Chitosan/Polyvinyl Alcohol blend doped with Hibiscus Sabdariffa L. extract. J Mol Struct 1197:603–609

    Article  CAS  Google Scholar 

  46. Elabbasy MT, Abd El-Kader MFH, Ismail AM, Menazea AA (2021) Regulating the function of bismuth (III) oxide nanoparticles scattered in Chitosan/Poly (Vinyl Pyrrolidone) by laser ablation on electrical conductivity characterization and antimicrobial activity. J Market Res 10:1348–1354

    CAS  Google Scholar 

  47. Sindhu S (2015) α-Bi 2 O 3 photoanode in DSSC and study of the electrode–electrolyte interface. RSC Adv 5(95):78299–78305

    Article  CAS  Google Scholar 

  48. Köhler R, Ohms G, Militz H, Viöl W (2018) Atmospheric pressure plasma coating of bismuth oxide circular droplets. Coatings 8(9):312

    Article  CAS  Google Scholar 

  49. Bera KK, Majumdar R, Chakraborty M, Bhattacharya SK (2018) Phase control synthesis of α, β and α/β Bi2O3 hetero-junction with enhanced and synergistic photocatalytic activity on degradation of toxic dye, Rhodamine-B under natural sunlight. J Hazard Mater 352:182–191

    Article  CAS  PubMed  Google Scholar 

  50. Patterson AL (1939) The Scherrer formula for X-ray particle size determination. Phys Rev 56(10):978

    Article  CAS  Google Scholar 

  51. Gutha Y, Pathak J, Zhang W, Zhang Y, Jiao X (2017) Antibacterial and wound healing properties of chitosan/poly(vinyl alcohol)/zinc oxide beads (CS/PVA/ZnO). Int J Biol Macromol 103:234–241

    Article  CAS  PubMed  Google Scholar 

  52. Fernandes Queiroz M, Melo K, Sabry D, Sassaki G, Rocha H (2014) Does the Use of Chitosan Contribute to Oxalate Kidney Stone Formation? Mar Drugs 13(1):141–158

    Article  PubMed  CAS  Google Scholar 

  53. Yan Y, Zhou Z, Cheng Y, Qiu L, Gao C, Zhou J (2014) Template-free fabrication of α-and β-Bi2O3 hollow spheres and their visible light photocatalytic activity for water purification. J Alloy Compd 605:102–108

    Article  CAS  Google Scholar 

  54. Khairnar SD, Shrivastava VS (2019) Photocatalytic degradation of chlorpyrifos and methylene blue using α-Bi 2 O 3 nanoparticles fabricated by sol–gel method. SN Appl Sci 1(7):1–10

    Article  CAS  Google Scholar 

  55. Hwang YC, Lee SH, Hwang IN, Kang IC, Kim MS, Kim SH, Oh WM (2009) Chemical composition, radiopacity, and biocompatibility of Portland cement with bismuth oxide. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 107(3):e96–e102

    Article  PubMed  Google Scholar 

  56. Shankar S, Jaiswal L, Aparna RSL, Prasad RGSV (2014) Synthesis, characterization, in vitro biocompatibility, and antimicrobial activity of gold, silver and gold silver alloy nanoparticles prepared from Lansium domesticum fruit peel extract. Mater Lett 137:75–78

    Article  CAS  Google Scholar 

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Acknowledgements

The authors express their appreciation to the Deanship of Scientific Research at King Khalid University, Saudi Arabia, for funding this work through research groups program under grant of number RGP.2/124/43.

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Authors and Affiliations

  1. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia

    Ahmad El Askary

  2. Chemistry Department, Faculty of Science, King Khalid University, P.O. Box 9004, Abha, 61413, Saudi Arabia

    Nasser S. Awwad

  3. Biology Department, Faculty of Science, King Khalid University, P.O. Box 9004, Abha, 61413, Saudi Arabia

    Hala A. Ibrahium

  4. Department of Semi Pilot Plant, Nuclear Materials Authority, P.O. Box 530, El Maadi, Egypt

    Hala A. Ibrahium

  5. Department of Chemistry, College of Science and Humanities, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia

    Moustapha Eid Moustapha

  6. Laser Technology Unit, Center of Excellent for Advanced Science, National Research Center, 12622, Dokki Giza, Egypt

    A. A. Menazea

  7. Spectroscopy Department, Physics Research Institute, National Research Centre, 12622, Dokki Giza, Egypt

    A. A. Menazea

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  1. Ahmad El Askary
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  2. Nasser S. Awwad
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  3. Hala A. Ibrahium
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  4. Moustapha Eid Moustapha
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  5. A. A. Menazea
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Correspondence to A. A. Menazea.

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Askary, A.E., Awwad, N.S., Ibrahium, H.A. et al. Structural, thermal, morphological and antibacterial activities of hybrid bio-nanocomposite Chitosan/Au/Bi2O3 for biomedical applications. J Polym Res 29, 269 (2022). https://doi.org/10.1007/s10965-022-03116-0

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  • DOI: https://doi.org/10.1007/s10965-022-03116-0

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