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Wound dressings based on chitosan and gelatin containing starch, sesame oil and banana peel powder for the treatment of skin burn wounds

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Abstract

A novel wound dressing based on chitosan (CS) and gelatin (GL) was prepared and the effect of potato-starch (ST), sesame oil (SO) and banana peel powder (BPP) on the physical and mechanical properties, cytocompatibility and wound healing capability of the films were evaluated. The mechanical results showed that the samples containing 5 wt% of potato-starch and 7 wt% of banana peel powder had the best mechanical properties (Elastic Modulus of 1930 MPa and Tensile Strength of 58.2 MPa). The scanning electron micrographs presented the uniform distribution of banana peel powder within the polymeric matrix up to 7 wt% of banana peel powder. By Adding banana peel powder to the film composition, the antibacterial activity of the films against E. coli and S. aureus bacteria increased. The MTT assay results revealed that the films containing banana peel powder had no toxicity and never caused cell death. In vivo experiments, using an animal model, demonstrated that the proliferation of blood vessels and angiogenesis along with connective tissues formations were accelerated considerably by the samples prepared in this study.

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  1. Department of Polymer Engineering, Shahreza Branch, Islamic Azad University, Shahreza, Iran

    Zhaleh Alborzi, Hossein Izadi-Vasafi & Faezeh Ghayoumi

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Alborzi, Z., Izadi-Vasafi, H. & Ghayoumi, F. Wound dressings based on chitosan and gelatin containing starch, sesame oil and banana peel powder for the treatment of skin burn wounds. J Polym Res 28, 61 (2021). https://doi.org/10.1007/s10965-021-02427-y

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