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An antibacterial composite system based on multi-responsive microgels hosting monodisperse gold nanoparticles

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Abstract

A multi-responsive microgel having response to pH, temperature, and salt concentration was successfully prepared using a water-soluble monomer. Microgels were readily prepared from 2-(N-morpholino)ethyl methacrylate (MEMA) via emulsion polymerization using glycidyl methacrylate as a comonomer cross-linker. The morpholino groups of MEMA residues of microgels were able to give complexation with metal containing anions such as AuCl4 − in acidic conditions. The reduction of aurate ions with sodium borohydride led to immobilized-gold nanoparticles (AuNP) in the microgel system. Average particle diameters of AuNPs were determined to be 10 ± 2 nm. The resulting AuNP-microgel system was examined as a nanoreactor for catalyst system and determined to be very effective in the reduction of 4-nitrophenol model reaction in aqueous media. AuNPs-microgel composite system had antibacterial properties against several Gram-positive and Gram-negative bacteria similar to amoxicillin. This P(MEMA-co-GMA) microgel is also very useful for different applications such as a host for metal nanoparticle production, a drug carrier or drug delivery system.

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Acknowledgements

The Scientific and Technological Research Council of Turkey is thanked for financial support (GR/111 T972). This work was also financially supported by the Scientific Research Project Supporting Commission of Eskisehir Osmangazi University (GR/201319C103).

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Authors and Affiliations

  1. Department of Polymer Science and Technology, Eskisehir Osmangazi University, 26480, Eskisehir, Turkey

    Damla Ulker, Serife B. Sezgin & Vural Bütün

  2. Department of Chemistry, Eskisehir Osmangazi University, 26480, Eskisehir, Turkey

    Cansel Tuncer & Vural Bütün

  3. Department of Biology, Graduate School of Natural and Applied Sciences, Eskisehir Osmangazi University, 26480, Eskisehir, Turkey

    Yagmur Toptas

  4. Department of Biology, Eskisehir Osmangazi University, 26480, Eskisehir, Turkey

    Ahmet Cabuk

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  1. Damla Ulker
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Correspondence to Vural Bütün.

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Ulker, D., Tuncer, C., Sezgin, S.B. et al. An antibacterial composite system based on multi-responsive microgels hosting monodisperse gold nanoparticles. J Polym Res 24, 169 (2017). https://doi.org/10.1007/s10965-017-1336-y

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