Abstract
In this paper, Poly(acrylic acid-co-2-hydroxyethyl methacrylate-co-2-acrylamido-2–methyl-1–propanesulfonic acid (AAc-HEMA-AMPS) microgels were synthesized by using an inverse suspension polymerization technique. The increase in the AMPS content of the microgels composition caused a large increase in water uptake. The morphology of the microgels was examined by environmental scanning electron microscopy (ESEM). The AMPS containing microgels had a mean particle diameter of 10 μm. The glass transition temperature of the microgels were examined by DSC and found that they show single Tg. Lidocaine (LD) and Methylene blue (MB) were used as model drugs for the investigation of drug release behavior of the microgels. Different drug release patterns were observed, for LD and MB loaded microgels. The release studies showed that some of the basic parameters affecting the drug release behavior of microgels were the specific and non-specific interactions between microgel and drug structure and pH of the dissolution medium. These hydrogels may be potential candidates for pH-sensitive applications.
Similar content being viewed by others
References
Dinarvand R, D’Emanuele A (1995) The use of thermoresponsive hydrogels for on–off release of molecules. J Control Release 36:221–227
Hoffman AS (1987) Application of thermally reversible polymers and hydrogels in therapeutics and diagnostics. J Control Release 6:297–305
Tao Y, Zhao J, Wu C (2005) Polyacrylamide hydrogels with trapped sulfonated polyaniline. Eur Polym J 41:1342–1349
Kayaman N, Kazan D, Erarslan A, Okay O, Baysal BM (1998) Structure and protein separation efficiency of poly(Nisopropylacrylamide) gels: effect of synthesis condition. J Appl Polym Sci 67:805–819
Taşdelen B, Kayaman-Apohan N, Güven O, Baysal BM (2004) Swelling and diffusion studies of poly(N-isopropylacrylamide/itaconic acid) copolymeric hydrogels in water and aqueous solutions of drugs. J Appl Polym Sci 91:911–915
Hirokawa Y, Tanaka T (1984) Volume phase transition in nonionic gels. J Chem Phys 81:6379–6380
Matsuo ES, Tanaka T (1988) Kinetics of discontinuous volume phase transition of gels. J Chem Phys 89:1695–1703
Li Y, Tanaka T (1989) Study of the universality class of the gel network system. J Chem Phys 90:5161–5166
Zhang QS, Zha LS, Ma JH, Liang BR (2007) A novel route to the preparation of poly(N-isopropylacrylamide) microgels by using inorganic clay as a crosslinker. Macromol Rapid Commun 28:116–120
Suarez IJ, Fernandez-Nieves A, Marquez M (2006) Swelling kinetics of poly(N-isopropylacrylamide) minigels. J Phys Chem B 110(51):25729–25733
Matsumura Y, Iwai K (2005) Synthesis and thermo-responsive behavior of fluorescent labeled microgel particles based on poly(N-isopropylacrylamide) and its related polymers. Polymer 46:10027–10034
Zhang J, Chu LY, Cheng CJ, Mi DF, Zhou MY, Ju XJ (2008) Graft-type poly(N-isopropylacrylamide-co-acrylic acid) microgels exhibiting rapid thermo- and pH-responsive properties. Polymer 49:2595–2603
van Vlerken LE, Vyas TK, Amiji MM (2007) Poly(ethylene glycol)-modified nanocarriers for tumor-targeted and intracellular delivery. Pharm Res 24:1405–1414
D’Emanuele A, Dinarvand R (1995) Preparation, characterization, and drug release from thermoresponsive microspheres. Int J Pharm 118:237–242
Oktar O, Caglar P, Seitz WR (2009) Chemical modulations of thermosensitive poly (N-isopropylacrylamide) microsphere swelling: a new strategy for chemical sensing. Sens Actuators B Chem 104:179–185
Fundueanu G, Constantin M, Ascenzi P (2009) Poly(N-isopropylacrylamide-co- acrylamide) cross-linked thermoresponsive microspheres obtained from preformed polymers: Influence of the physico-chemical characteristics of drugs on their release profiles. Acta Biomater 5:363–373
Tasdelen B, Kayaman-Apohan N, Mısırlı Z, Guven O, Baysal BM (2005) Characterization and drug release properties of poly(N-isopropylacrylamide) microspheres having poly(itaconic acid) graft chains. J Appl Polym Sci 97:1115–1124
Akdemir ZS, Kayaman-Apohan N (2007) Preparation and diffusion studies of poly (N- isopropylacrylamide)/poly (N-vinylpyrrolidone) full-IPN hydrogels. Polym Adv Tech 18:932–939
Park TG, Hoffman AS (1994) Estimation of temperature dependent pore size in poly(N-isopropyl acrylamide) hydrogel beads. Biotechnol Prog 10:82–86
Durmaz S, Okay O (2000) Acrylamide/2-acrylamido-2-methylpropane sulfonic acid sodium salt-based hydrogels: synthesis and characterization. Polymer 41:3693–3704
Ma L, Zhang L, Yang JC, Xie XM (2002) Improvement in the water-absorbing properties of superabsorbent polymers (acrylic acid-co-acrylamide) in supercritical CO2. J Appl Polym Sci 86:2272–2278
Bhardwaj P, Singh V, Aggarwal S, Mandal UK (2009) Poly(acrylamide-co-2-acrylamido-2-methyl-1-propanesulfonic Acid) Nanogels made by Inverse Microemulsion Polymerization. J Macromol Sci Part A: Pure and Appl Chem 46:1083–1094
Ng LT, Nakayama H, Kaetsu I, Uchida K (2009) Photocuring of stimulus responsive membranes for controlled-release of drugs having different molecular weights. Radiat Phys Chem 73:117–123
Yan S, Yin J, Yu Y, Luo K, Chen X (2009) Thermo- and pH-sensitive poly(vinylmethyl ether)/carboxymethylchitosan hydrogels crosslinked using electron beam irradiation or using glutaraldehyde as a crosslinker. Polym Int 58:1246–1251
Ng LT, Ng KS (2008) Photo-cured pH-responsive polyampholyte-coated membranes for controlled release of drugs with different molecular weights and charges. Radiat Phys Chem 77:192–199
Greesh N, Hartmann PC, Cloete V, Sanderson RD (2008) Adsorption of 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) and related compounds onto montmorillonite clay. J Colloid Interface Sci 319(1):2–11
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Nart, Z., Kayaman-Apohan, N. Preparation, characterization and drug release behavior of poly(acrylic acid–co-2-hydroxyethyl methacrylate-co-2-acrylamido-2-methyl-1-propanesulfonic acid) microgels. J Polym Res 18, 869–874 (2011). https://doi.org/10.1007/s10965-010-9483-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10965-010-9483-4