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Poly(2-oxazoline) hydrogels by photoinduced thiol-ene “click” reaction using different dithiol crosslinkers

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Abstract

Fabrication of a library of biocompatible hydrogels by photoinduced thiol-ene “click” reaction is described. The hydrogels are based on two different statistical copolymers consisting of 2-butenyl-2-oxazoline (EnOx) with either 2-methyl-2-oxazoline (MeOx) or 2-ethyl-2-oxazoline (EtOx). Crosslinking is achieved via pendant vinyl groups of EnOx in the copolymers with selected dithiol crosslinkers, namely dithiothreitol, 1,3-propanedithiol, 1,6-hexanedithiol, and 1,9-nonanedithiol by thiol-ene photocoupling. On the basis of different polarity and flexibility of particular dithiols and three different molar ratios to double bonds, it is possible to control swelling and mechanical characteristics of resulting hydrogels. Biocompatibility of all hydrogel types is verified by determination of toxicity of hydrogel extracts and contact direct toxicity towards mice 3T3 fibroblast cell line. The resulting low toxicity of all prepared hydrogels predetermines its utilization in biomedicine.

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Acknowledgements

The authors acknowledge the Slovak Grant Agency VEGA for the financial support in the project No. 2/0163/15 and the Slovak Research and Development Agency for financial support in the project No. APVV-15-0485. This work was also supported by the M-ERA.NET Transantional Call 2013 with the acronym M2Neural. The authors are thankful to Angela Kleinová for FTIR measurements and Ondrej Slučiak for his practical advice and comments.

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Authors and Affiliations

  1. Polymer Institute of the Slovak Academy of Sciences, Dúbravská cesta 9, 845 41, Bratislava, Slovakia

    Petra Šrámková, Anna Zahoranová, Zuzana Kroneková, Alena Šišková & Juraj Kronek

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  1. Petra Šrámková
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  2. Anna Zahoranová
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  3. Zuzana Kroneková
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  4. Alena Šišková
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  5. Juraj Kronek
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Correspondence to Juraj Kronek.

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Šrámková, P., Zahoranová, A., Kroneková, Z. et al. Poly(2-oxazoline) hydrogels by photoinduced thiol-ene “click” reaction using different dithiol crosslinkers. J Polym Res 24, 82 (2017). https://doi.org/10.1007/s10965-017-1237-0

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  • DOI: https://doi.org/10.1007/s10965-017-1237-0

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