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Synthesis and bioimmunological efficiency of poly(2-oxazolines) containing a free amino group

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Abstract

Novel amphiphilic copolymers on the basis of 2-oxazolines containing a free amino group were prepared. The copolymers were synthesized by the living cationic polymerization of 2-ethyl-2-oxazoline (ETOX) and 2-(4-aminophenyl)-2-oxazoline (APOX). The main goal of this work was the synthesis of water soluble polymer material with the defined number of functional groups necessary for the attachment of proteins and polysaccharides. A high concentration of free amino groups allows immobilization of various biosubstances, e.g. drugs, proteins or polysaccharides. Thermal properties have been studied with respect to the composition of the copolymers. Cytotoxicity and the bioimmunological efficiency of the selected copolymer were studied.

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Acknowledgements

This work was supported by Project No. 2/0157/09 from the Slovak Scientific Grant Agency and Project No. 003206 from the Slovak Research and Development Agency. The authors thank Dr. I. Lacik for providing the molecular characteristics of the synthesized polymers and copolymers.

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Authors and Affiliations

  1. Polymer Institute, Centre of Excellence GLYCOMED, Slovak Academy of Sciences, Dubravska cesta 9, 84236, Bratislava, Slovakia

    J. Kronek, J. Lustoň, Z. Kroneková, N. Petrenčíková & I. Janigová

  2. Institute of Chemistry, Centre of Excellence GLYCOMED, Slovak Academy of Sciences, Dubravska cesta 9, 84538, Bratislava, Slovakia

    E. Paulovičová, P. Farkaš & L. Paulovičová

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  1. J. Kronek
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  2. J. Lustoň
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  3. Z. Kroneková
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  4. E. Paulovičová
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  5. P. Farkaš
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  6. N. Petrenčíková
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  7. L. Paulovičová
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  8. I. Janigová
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Correspondence to J. Kronek.

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Kronek, J., Lustoň, J., Kroneková, Z. et al. Synthesis and bioimmunological efficiency of poly(2-oxazolines) containing a free amino group. J Mater Sci: Mater Med 21, 879–886 (2010). https://doi.org/10.1007/s10856-009-3949-0

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  • DOI: https://doi.org/10.1007/s10856-009-3949-0

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