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Magnetic graphene oxide mesoporous silica hybrid nanoparticles with dendritic pH sensitive moieties coated by PEGylated alginate-co-poly (acrylic acid) for targeted and controlled drug delivery purposes

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Abstract

In this study synthesis of a drug delivery system (DDS) is described which has several merits over its counterparts. In order to synthesize this nano-carrier, graphene oxide nano-sheets are used to accommodate MCM-41 nanoparticles. Furthermore Fe3O4 nanoparticles are introduced to this nano-material to produce a traceable nanoparticle. Since cancerous tissues have lower pH than healthy tissues, pH-sensitive oligomers are attached to this nano-material. Finally the nano-carrier is wrapped by a biocompatible shell (PEGylated sodium alginate); this polymeric shell makes the DDS capable of a more controllable drug release. By measuring in vitro situation, ‘loading content%’ and ‘entrapment efficiency%’ proves to be 21 and 93.5 % respectively. In an acidic medium, the drug carrier without a polymeric shell (naked DDS) releases the whole of its drug content in 18 h, while the drug carrier with a polymeric shell (core-shell DDS) releases 45 % of its drug content during 48 h.

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Authors and Affiliations

  1. Polymer Laboratory, Chemistry Department, Sharif University of Technology, P.O. Box 11155-8639, Tehran, Iran

    Ali Pourjavadi, Alireza Shakerpoor & Zahra Mazaheri Tehrani

  2. Department of Chemistry, Faculty of Science, Kuwait University, P.O. Box 5969, Safat, 13060, Kuwait

    Ali Bumajdad

Authors
  1. Ali Pourjavadi
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  2. Alireza Shakerpoor
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  3. Zahra Mazaheri Tehrani
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  4. Ali Bumajdad
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Correspondence to Ali Pourjavadi.

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Pourjavadi, A., Shakerpoor, A., Tehrani, Z.M. et al. Magnetic graphene oxide mesoporous silica hybrid nanoparticles with dendritic pH sensitive moieties coated by PEGylated alginate-co-poly (acrylic acid) for targeted and controlled drug delivery purposes. J Polym Res 22, 156 (2015). https://doi.org/10.1007/s10965-015-0799-y

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  • DOI: https://doi.org/10.1007/s10965-015-0799-y

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