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Dispersion polymerization of L-lactide in supercritical carbon dioxide

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Abstract

Triblock (A-B-A) oligomers of ε-caprolactone (ε-CL) (A) and poly(ethylene glycol) with an average molecular weight of 400 (PEG400) (B) were synthesized with three different molecular weight in the range of 2–6 kDa by changing the ratio of PEG400/ε-CL. These oligomers were then used in dispersion polymerization of L-lactide in supercritical carbon dioxide (scCO2) as stabilizers. 5% stabilizer in the polymerization recipe allowed synthesis of poly(L-lactide) (PLLA) in scCO2 in the powder form with a weight average molecular weight of around 60 kDa with polymerization yields around 80%. Interestingly, there was almost no effect of stabilizer molecular weight on polymerization. L-lactide polymerization in scCO2 without any stabilizer was also possible but both the PLLA molecular weight and polymerization yield were lower, and the product was as aggregates instead of powders. A stabilizer concentration of 5% in the polymerization recipe was found adequate. Further increases in the stabilizer load resulted lower molecular weights and lower yields.

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Acknowledgements

This study was supported by Turkish Scientific and Technological Research Council of Turkey (TUBITAK Projects no: 108M155 and 105T509), Turkish Ministry of Industry (San-Tez Project No: 00020.STV.2006-1) and EU-FP6-NoE:Expertissues. Erhan Pişkin was supported by Turkish Academy of Sciences as a full member. Supports of Biyomedtek and Hacettepe University-Center for Bioengineering is also kindly acknowledged.

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Authors and Affiliations

  1. Chemical Engineering Department, Ankara University, Beşevler, Ankara, 06100, Turkey

    Mehmet Yılmaz, Nuray Yıldız & Ayla Çalımlı

  2. Chemical Engineering Department-Bioengineering Division-Center for Bioengineering and Biyomedtek, Hacettepe University, Beytepe, Ankara, 06800, Turkey

    Sinan Eğri & Erhan Pişkin

Authors
  1. Mehmet Yılmaz
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  2. Sinan Eğri
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  3. Nuray Yıldız
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  4. Ayla Çalımlı
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Correspondence to Ayla Çalımlı.

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Yılmaz, M., Eğri, S., Yıldız, N. et al. Dispersion polymerization of L-lactide in supercritical carbon dioxide. J Polym Res 18, 975–982 (2011). https://doi.org/10.1007/s10965-010-9497-y

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  • DOI: https://doi.org/10.1007/s10965-010-9497-y

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