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Volumetric and UV Absorption Studies on Interactions of an Active Pharmaceutical Ingredient Ionic Liquid (API-IL) Domiphen l-Proline with Amino Acids and Glycyl Dipeptides in Aqueous Solution at T = (293.15–308.15) K

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Abstract

Novel ionic liquids containing the domiphen cation, as an active pharmaceutical ingredient ionic liquid (API-IL), domiphen l-proline ([DOM][l-PRO]) was synthesized and the interactions of domiphen l-proline with some small biomolecules (amino acids and glycyl dipeptides) were investigated at different temperatures from density and UV–Vis spectroscopy measurements. The apparent molar volumes, standard partial molar volumes, transfer volumes, hydration numbers and partial molar expansibilities of small biomolecules have been calculated. Group contributions of amino acids/dipeptides to the standard partial molar volume were determined and the contributions from the zwitterionic end group (NH3 +, COO−), CH2 and (CH2CONH) groups have been obtained. The binding constants between small biomolecules and [DOM][l-PRO] were also obtained. A detailed insight into the physicochemical interactions in the ternary systems was obtained through the perusal of these parameters. Compared with [DOM][Br], [DOM][l-PRO] interacts with small biomolecules weakly.

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Acknowledgements

The project was financially supported by the Natural Science Foundation of China (No. 21573199).

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Authors and Affiliations

  1. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, Henan, China

    Zhenning Yan, Wenwen Chu, Shuangxia Shen & Limin Ma

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  1. Zhenning Yan
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Correspondence to Zhenning Yan.

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Yan, Z., Chu, W., Shen, S. et al. Volumetric and UV Absorption Studies on Interactions of an Active Pharmaceutical Ingredient Ionic Liquid (API-IL) Domiphen l-Proline with Amino Acids and Glycyl Dipeptides in Aqueous Solution at T = (293.15–308.15) K. J Solution Chem 46, 1658–1679 (2017). https://doi.org/10.1007/s10953-017-0671-2

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