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Solubility Data of Diazepam in Binary and Ternary Mixtures of PEGs 200 and 400 with N-Methyl Pyrrolidone and Water at 298.2 K: Experimental Data and Modeling

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Abstract

Experimental solubilities of diazepam in binary and ternary solvents of polyethylene glycols 200 and 400 with N-methyl pyrrolidone and water at T = 298.2 K are reported. The Jouyban–Acree model was used to fit solubility data of diazepam in the binary and ternary solvent mixtures (106 data points) in which the overall mean relative deviations (OMRD %) is 13.1 % and the prediction OMRD % is 31.7 %. The combined version of the Jouyban–Acree model with Hansen solubility parameters was used for fitting and predicting the solubility data and the OMRDs % are 10.0 and 20.8 %, respectively. Also, the previously proposed trained versions of the Jouyban–Acree model were used for predicting the reported data in this work and all results are listed in the tables. The density of the solute-free solvent mixtures were measured and employed to calculate the constants of the Jouyban–Acree model and then the densities of the saturated solutions were predicted.

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Acknowledgments

The authors are grateful for financial support from Zanjan University of Medical Sciences, Iran (No. A-11-387-1).

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Authors and Affiliations

  1. Faculty of Pharmacy, Zanjan University of Medical Sciences, 45139, Zanjan, Iran

    Shahla Soltanpour, Azade Taheri & Zahra Bastami

  2. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Vahid Panahi-Azar

  3. Drug Applied Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, 51664, Tabriz, Iran

    Abolghasem Jouyban

  4. Pharmaceutical Engineering Laboratory School of Chemical Engineering, College of Engineering, University of Tehran, P.O. Box 11155/4563, Tehran, Iran

    Abolghasem Jouyban

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  1. Shahla Soltanpour
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  2. Vahid Panahi-Azar
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  5. Abolghasem Jouyban
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Correspondence to Shahla Soltanpour.

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Soltanpour, S., Panahi-Azar, V., Taheri, A. et al. Solubility Data of Diazepam in Binary and Ternary Mixtures of PEGs 200 and 400 with N-Methyl Pyrrolidone and Water at 298.2 K: Experimental Data and Modeling. J Solution Chem 42, 2281–2295 (2013). https://doi.org/10.1007/s10953-013-0106-7

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