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Theoretical and Experimental Study of the Thermodynamic Solubility of Pioglitazone HCl in Ethanol, N-Methyl Pyrrolidone or Propylene Glycol + Water Mixtures at Various Temperatures

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Abstract

The solubilities of pioglitazone HCl (99 data points) in binary solvent mixtures of ethanol, N-methyl pyrrolidone (NMP) or propylene glycol (PG) + water are reported at three temperatures ranging from 298.2 to 308.2 K. Three different cosolvency models, those of Yalkowsky, Jouyban–Acree and combined version of the Jouyban–Acree model with the van’t Hoff approach, have been used for correlating the reported data, and the corresponding overall mean relative deviations (OMRDs) are 88.9, 19.1 and 14.8%, respectively. Also, three previously trained versions of the Jouyban–Acree model have been used for predicting the solubilities of pioglitazone HCl in the aqueous binary solvent mixtures of ethanol, NMP and PG which the prediction OMRDs are 38.9, 93.0 and 50.0%, respectively.

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Acknowledgements

This paper resulted from a Pharm.D Thesis with the proposal number of (A-11-387-4). The authors are grateful for financial support from Zanjan University of Medical Sciences, Iran.

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Authors and Affiliations

  1. Medicinal Chemistry Department, Faculty of Pharmacy, Zanjan University of Medical Sciences, Ghavazangh Rd., Zanjan, 45139, Iran

    Shahla Soltanpour & Fatemeh Zohrabi

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  1. Shahla Soltanpour
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  2. Fatemeh Zohrabi
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Correspondence to Shahla Soltanpour.

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Soltanpour, S., Zohrabi, F. Theoretical and Experimental Study of the Thermodynamic Solubility of Pioglitazone HCl in Ethanol, N-Methyl Pyrrolidone or Propylene Glycol + Water Mixtures at Various Temperatures. J Solution Chem 46, 139–149 (2017). https://doi.org/10.1007/s10953-016-0553-z

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  • DOI: https://doi.org/10.1007/s10953-016-0553-z

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