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A New Approach for Thermodynamic Studies on Binding of Some Metal Ions with Human Growth Hormone

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Abstract

A thermodynamic study on the interaction between Mg2+, Ni2+ and Co2+ ions (M2+) and human growth hormone (hGH) was made at 27 °C in aqueous NaCl solutions using isothermal titration calorimetry. Gholamreza Rezaei Behbehani’s solvation model (GRB) was used to model the enthalpies of M2++hGH interactions over the studied range of metal ion concentrations. The solvation parameters derived from the solvation model were attributed to a structural change of hGH due to its interactions with the metal ion.

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Authors and Affiliations

  1. Chemistry Department, Imam Khomeini International University, Qazvin, Iran

    G. Rezaei Behbehani

  2. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran

    A. Divsalar, A. A. Saboury & N. Gheibi

  3. Departament of Biological Sciences, Tarbiat Moallem University, Tehran, Iran

    A. Divsalar

  4. Department of Physiology and Medical Physics, Qazvin University of Medical Sciences, Qazvin, Iran

    N. Gheibi

Authors
  1. G. Rezaei Behbehani
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  2. A. Divsalar
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  3. A. A. Saboury
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  4. N. Gheibi
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Correspondence to G. Rezaei Behbehani.

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Rezaei Behbehani, G., Divsalar, A., Saboury, A.A. et al. A New Approach for Thermodynamic Studies on Binding of Some Metal Ions with Human Growth Hormone. J Solution Chem 37, 1645–1655 (2008). https://doi.org/10.1007/s10953-008-9339-2

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  • DOI: https://doi.org/10.1007/s10953-008-9339-2

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