Journal of Porous Materials

, Volume 26, Issue 1, pp 217–226 | Cite as

Chitosan oligosaccharide coated mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications

  • Madhappan Santha Moorthy
  • Giang Hoang
  • Panchanathan Manivasagan
  • Sudip Mondal
  • Thi Tuong Vy Phan
  • Hyehyun Kim
  • Junghwan OhEmail author


Biopolymer-coated drug delivery system with high drug-loading efficiency and pH-stimuli responsive drug release to the target site receives much research interest in cancer therapy. In this study, we have synthesized a marine biopolymer, namely chitosan oligosaccharide (COS) coated mesoporous silica nanoparticle (MSNs@COS NPs) system for pH-responsive drug delivery applications. The COS coating onto the silica nanoparticles was performed through metal–ligand complex coordination approaches. The prepared MSNs@COS NPs system were characterized by low-angle X-ray diffraction (XRD), Fourier-transform infrared (FTIR), N2 adsorption–desorption and transmission electron microscopic (TEM), and thermogravimetric analyses. The COS-coated MSNs@COS NPs system shows high drug-loading capacity, good drug retention efficiency under physiological pH (pH 7.4) conditions, and an intracellular pH-responsive drug release behavior under acidic pH (pH 6.5, 5.0, and 4.0) environments. Furthermore, the biocompatibility and the intracellular uptake behavior of the MSNs@COS NPs system were evaluated by using MDA-MB-231 cells. The in vitro cytotoxicity and fluorescence microscopic analysis results evidenced that the synthesized MSNs@COS NPs system is biocompatible and could be readily taken up by MDA-MB-231 cells. Therefore, we believe that the proposed system could be applicable for pH-stimuli responsive controlled drug delivery applications in cancer therapy.


Silica nanoparticles pH-Stimuli Chitosan oligosaccharide Drug delivery Biopolymer 



This research was supported by a grant from the Marine Biotechnology Program (20150220) funded by the Ministry of Oceans and Fisheries, Republic of Korea.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Madhappan Santha Moorthy
    • 1
  • Giang Hoang
    • 1
  • Panchanathan Manivasagan
    • 1
  • Sudip Mondal
    • 1
  • Thi Tuong Vy Phan
    • 2
  • Hyehyun Kim
    • 2
  • Junghwan Oh
    • 1
    • 2
    Email author
  1. 1.Department of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus)Pukyong National UniversityBusanRepublic of Korea
  2. 2.Marine-Integrated Bionics Research CenterPukyong National UniversityBusanRepublic of Korea

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