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Cysteine and N-acetyl cysteine encapsulated mesoporous silica: synthesis, characterization and influence of parameters on in-vitro controlled release

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Abstract

Pro-drug, cysteine loaded mesoporous silica materials with hexagonal (MCM-41) and cubic (MCM-48) geometry were synthesized by incipient wetness and soaking technique. The structure and properties of these synthesized materials were investigated by various physico-chemical techniques such as FT-IR, Nitrogen adsorption-desorption, XRD and TEM. An in-vitro release study of cysteine from these synthesized materials in SBF was carried out under stirring as well as static conditions. Effect of synthesis method as well as effect of geometry of carrier on release profile of drugs was also examined. Based on the obtained results for pro-drug, controlled release of real drug, N-acetyl cysteine was also carried out under optimized conditions. Release results shows that N-acetyl cysteine release was found to be more controlled as compare to that of cysteine from both mesoporous carriers. A study on release mechanism and release kinetics was also carried out using Higuchi model and first order release kinetic model.

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Acknowledgements

Prof. Anjali Patel is thankful to Council of Scientific and Industrial Research (CSIR), New Delhi, project no. [02(0174)/13/EMR-II] for the financial support. Dr. Soyeb Pathan is thankful to the same for the award of a Research Associate ship. Ms. Priyanka Solanki is also thankful to University Grant commission (UGC), New Delhi for the award of Junior Research Fellowship.We are also thankful to Department of Chemistry, The M. S. University of Baroda, for N2 adsorption–desorption analysis.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, 390002, India

    Soyeb Pathan, Priyanka Solanki & Anjali Patel

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  1. Soyeb Pathan
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  2. Priyanka Solanki
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  3. Anjali Patel
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Correspondence to Anjali Patel.

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Pathan, S., Solanki, P. & Patel, A. Cysteine and N-acetyl cysteine encapsulated mesoporous silica: synthesis, characterization and influence of parameters on in-vitro controlled release. J Porous Mater 24, 1105–1115 (2017). https://doi.org/10.1007/s10934-016-0351-4

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