Skip to main content

Advertisement

SpringerLink
Log in

Influence of pore size and surface area of mesoporous silica materilas (MCM-41 and KIT-6) on the drug loading and release

  • Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications
  • Published:
Journal of Sol-Gel Science and Technology Aims and scope Submit manuscript

Abstract

Mesoporous silica KIT-6 and MCM-41 with different pore sizes has been prepared through the sol–gel and hydrothermal method, respectively. The synthesized mesoporous materials were modified by a chemical modification using 3-aminopropyl triethoxysilane (APTES) to obtain KIT-6-NH2 and MCM-41-NH2 as drug delivery carriers. The mesostructure properties was fully characterized by scanning electron microscope (SEM), N2 sorption isotherm, Fourier transform infrared (FT-IR), X-ray diffraction (XRD). Loading of resveratrol (RSV) drug as a model into synthesized mesoporous carriers and amine functionalized forms were studied using thermogravimetric analysis (TGA) and UV–visible spectroscopy (UV–Vis). The loading uptake and release behavior of RSV was highly dependent on the textural properties (such as pore size and surface area) of mesoporous silica and modified carriers. The release of drugs was carefully studied in different pH. The effect of the synthesized carriers and RSV@mesoporous drug carriers on MCF-7 human breast cancer cell line viability was evaluated. Both carriers alone revealed no toxicity to MCF-7 cancer cells. But, RSV@carriers or RSV@modified carriers indicated an inhibition of cell livability, when compared to the non-encapsulated drug. RSV@modified mesoporous carriers demonstrated cell viability inhibition better than RSV@mesoporous carriers. The inhibition of cell viability of RSV@modified mesoporous carriers depends on surface area and functionalized groups of carriers more than pore size. First order, Higuchi, HixsoneCrowell and KorsmeyerePeppas release kinetic models were applied to the experimental data and the release was found to obey a first-order rate kinetic.

RSV@MCM-41-NH2 as a DDS caused the slow release of resveratrol, growing the bioavailability of the drug.

Highlights

  • The Resveratrol (RSV) is an experimental anticancer drug.

  • MCM-41 and KIT-6 were used as carriers for encapsulation of RSV drug.

  • The loading and release of RSV depends on surface area and pore size of carriers.

  • Amino groups play an important role in increased drug loading and release rate.

  • The effect of RSV@carriers was evaluated on MCF-7 human breast cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Scheme 2
Scheme 3
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9

Similar content being viewed by others

References

  1. Wise DL (2000) Handbook of Pharmaceutical Controlled Release. Technology, 1st edn. Marcel Dekker Inc., New York

    Google Scholar 

  2. Brigger I, Dubernet C, Couvreur P (2002) Nanoparticles in cancer therapy and diagnosis. Adv Drug Deliv Rev 54:631–651

    Article  Google Scholar 

  3. Chan S, Fauchet PM, Li Y, Rothberg LJ, Miller Bl (2000) Porous silicon microcavities for biosensing applications. Phys Status Solidi A 182:541–546

    Article  Google Scholar 

  4. Dancil KPS, Greiner DP, Sailor MJ (1999) A porous silicon optical biosensor: detection of reversible binding of IgG to a protein A-modified surface. J Am Chem Soc 121:7925–7930

    Article  Google Scholar 

  5. Coffer JL, Whitehead MA, Nagesha DK (2005) Porous silicon-based scaffolds for tissue engineering and other biomedical applications. Phys Status Solidi A 202:1451–1455

    Article  Google Scholar 

  6. Canham LT, Reeves CL, Loni A (1997) Calcium phosphate nucleation on porous silicon: factors influencing kinetics in acellular simulated body fluids. Thin Sol Films 297:304–307

    Article  Google Scholar 

  7. Canham LT, Reeves CL, King DO, Branfield PJ, Crabb JG, Ward MCL (1996) Bioactive polycrystalline silicon. Adv Mater 8:850–852

    Article  Google Scholar 

  8. Anglin EJ, Schwartz MP, Ng VP, Perelman LA, Sailor MJ (2004) Engineering the chemistry and nanostructure of porous silicon Fabry–Pérot films for loading and release of a steroid. Langmuir 20:11264–11269

    Article  Google Scholar 

  9. Charnay C, Begu S, Tourne-Peteilh C, Nicole L, Lerner DA, Devoisselle JM (2004) Inclusion of ibuprofen in mesoporous templated silica: drug loading and release property. Eur J Pharm Biopharm 57:533–540

    Article  Google Scholar 

  10. Coffer JL, Montchamp JL, Aimone JB, Weis RP (2003) Routes to calcifled porous silicon: implications for drug delivery and biosensing. Phys Status Solidi A 197:336–339

    Article  Google Scholar 

  11. Vaccari L, Canton D, Zaffaroni N, Villa R, Tormen M, di Fabrizio E (2006) Porous silicon as drug carrier for controlled delivery of doxorubicin anticancer agent. Microelectron Eng 83:1598–1601

    Article  Google Scholar 

  12. Salonen J, Kaukonen AM, Hirvonen J, Lehto VP (2008) Mesoporous silicon in drug delivery applications. J Pharm Sci 97:632–653

    Article  Google Scholar 

  13. Ayad MM, Salahuddin NA, Elnasr AA, Torad NL (2016) name functionalized mesoporous silica KIT-6 as a controlled release drug delivery. Microporous Mesoporous Mater 229:166–177

    Article  Google Scholar 

  14. Slowing II, Vivero-Escoto JL, Wu CW, Lin VSY (2008) Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers. Adv Drug Deliv Rev 60:1278–1288

    Article  Google Scholar 

  15. Zhang Q, Neoh KQ, Xu L, Lu S, Kang ET, Mahendran R, Chiong E (2014) Functionalized mesoporous silica nanoparticles with mucoadhesive and sustained drug release properties for potential bladder cancer therapy. Langmuir 30:6151–6161

    Article  Google Scholar 

  16. Popat A, Hartono SB, Stahr F, Liu J, Qiao SZ, Lu G (2013) Mesoporous silica nanoparticles for bioadsorption, enzyme immobilization, and delivery carriers. Nanoscale 3:2801–2818

    Article  Google Scholar 

  17. Sharma KK, Asefa T (2007) Efficient bifunctional nanocatalysts by simple post grafting of spatially-isolated catalytic groups on mesoporous materials. Angew Chem Int Ed 46:2879–2882

    Article  Google Scholar 

  18. Regi MV, Ramila A, del Real RP, Perez-Pariente J (2001) A new property of MCM-41: drug delivery system. Chem Mater 13:308–311

    Article  Google Scholar 

  19. Manzano M, Aina V, Arean CO, Balas F, Cauda V, Collila M, Delgado MR, Regi MV (2008) Studies on MCM-41 mesoporous silica for drug delivery: effect of particle morphology and amine functionalization. Chem Eng J 137:30–37

    Article  Google Scholar 

  20. Bensacia N, Fechete I, Moulay S, Hulea O, Boos A, Garin F (2014) Kinetic and equilibrium studies of lead (II) adsorption from aqueous media by KIT-6 mesoporous silica functionalized with –COOH. Comptes Rendus Chim 17:869–880

    Article  Google Scholar 

  21. Sanjini NS, Velmathi S (2013) Synthesis of gallium doped mesoporous KIT-6 for the photocatalytic degradation of dye. Asian J Chem 25:S69–S72

    Google Scholar 

  22. Zhao H, Liu S, Wang R, Zhang T (2015) Humidity-sensing properties of LiCl-loaded 3D cubic mesoporous silica KIT-6 composites. Mater Lett 147:54–57

    Article  Google Scholar 

  23. Fazaeli R, Aliyan H, Foroushani SP, Mohagheghian Z, Heidari Z (2013) Mesoporous silica KIT-6 Heterogeneous catalysis Polyoxotungstate. Iran J Catal 3:129–137

    Google Scholar 

  24. Duan A, Li T, Zhao Z, Liu B, Zhou X, Jiang G, Liu J, Wei Y, Pan H (2015) Synthesis of hierarchically porous L-KIT-6 silica–alumina material and the super catalytic performances for hydrodesulfurization of benzothiophene. Appl Catal B Environ 165:763–773

    Article  Google Scholar 

  25. Hu B, Liu H, Tao K, Xiong C, Zhou S (2013) Highly active doped mesoporous KIT-6 catalysts for metathesis of 1-butene and ethene to propene: the influence of neighboring environment of w species. J Phys Chem C 117:26385–26395

    Article  Google Scholar 

  26. Kalepu S, Nekkanti V (2015) Insoluble drug delivery strategies: review of recent advances and business prospects. Acta Pharm Sin B 5:442–453

    Article  Google Scholar 

  27. Kundu JK, Surh YJ (2008) Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives. Cancer Lett 269:243–261

    Article  Google Scholar 

  28. Jang MS, Cai EN, Udeani GO, Slowing KV, Thomas CF, Beecher CWW, Fong HSS, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275:218–220

    Article  Google Scholar 

  29. Neves AR, Lúcio M, Lima JLC, Reis S (2012) Resveratrol in medicinal chemistry: a critical review of its pharmacokinetics, drug-delivery, and membrane interactions. Curr Med Chem 19:1663–1681

    Article  Google Scholar 

  30. Stervbo U, Vang O, Bonnesen CA (2007) A reviews of the content of the putative chemopreventive phytoalexin resveratrol in red wine. Food Chem 101:449–457

    Article  Google Scholar 

  31. Latifi L, Sohrabnezhad Sh, Hadavi M (2017) Mesoporous silica as a support for poorly soluble drug: influence of pH and amino group on the drug release. Microporous Mesoporous Mater 250:148–157

    Article  Google Scholar 

  32. Wang W, Qi R, Shan W, Wang X, Jia Q, Zhao J, Zhang C, Ru H (2014) Synthesis of KIT-6 type mesoporous silicas with tunable pore sizes, wall thickness and particle sizes via the partitioned cooperative self-assembly process. Micro Mesoporus Mater 194:167–173

    Article  Google Scholar 

  33. Moller K, Bein T (1998) Inclusion chemistry in periodic mesoporous hosts. Chem Mater 10:2950–2963

    Article  Google Scholar 

  34. Zhu Y, Shi J, Li Y, Chen H, Shen W, Dong X (2005) Storage and release of ibuprofen drug molecules in hollow mesoporous silica spheres with modified pore surface. Microporous Mesoporous Mater 85:75–81

    Article  Google Scholar 

  35. de Cássia da Silva R, Teixeira JA, Nunes WDG (2017) Resveratrol: a thermoanalytical study. Food Chem 237:561–565

    Article  Google Scholar 

  36. Bruinsma PJ, Kim AY, Liu J, Baskaran S (1997) Mesoporous silica synthesized by solvent evaporation: spun fibers and spray-dried hollow spheres. Chem Mater 9:2507–2512

    Article  Google Scholar 

  37. Sathish M, Viswanathan B, Viswanathan RP (2006) Alternate synthetic strategy for the preparation of CdS nanoparticles and its exploitation for water splitting. Int J Hydrog 31:891–898

    Article  Google Scholar 

  38. Huh S, Chen HT, Wiench JW, Pruski M, Lin SY (2005) Cooperative catalysis by general acid and base bifunctionalized mesoporous silica nanospheres. Angew Chem Int Ed 44:1826–1830

    Article  Google Scholar 

  39. Giraldo LF, Lopez BL, Perez L, Urrego S, Sierra L, Mesa M (2007) Mesoporous silica applications. Macromol Symp 258:129–141

    Article  Google Scholar 

  40. Yang H, Feng Q (2010) Diorect synthesis of pore-expanded amino functionalized mesoporous silicas with dimethydecylamine and the effect expander dosage on their characterization and decolorization of sulphonated dyes. Micro Mesoporus Mater 135:124–130

    Article  Google Scholar 

  41. Anbia M, Amirmahmoodi S (2011) Adsorption of phenolic compounds from aqueous solutions using functionalizedSBA-15 as a nano-sorbent. Sci Iran C 18:446–452

    Article  Google Scholar 

  42. Billes F, Mohammed-Ziegler I, Mikosch H, Tyihák E (2007) Vibrational spectroscopy of resveratrol. Spectrochim Acta A 68:669–679

    Article  Google Scholar 

  43. Gao L, Sun JH, Li YZ (2011) Functionalized bimodal mesoporous silicas as carriers for controlled aspirin delivery. J Solid State Chem 184:1909–1914

    Article  Google Scholar 

  44. Gerweck LE, Seetharaman K (1996) Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. Cancer Res 56:1194–1198

    Google Scholar 

  45. Maria G, Berger D, Nastase S, Luta I (2012) Kinetic studies on the irinotecan release based on structural properties of functionalized mesoporous-silica supports. Microporous Mesoporous Mater 149:25–35

    Article  Google Scholar 

  46. Popova MD, Szegedi A, Kolev IN, Mih_aly J, Tzankov BS, Momekov GT, Lambov NG, Yoncheva KP (2012) Carboxylic modified spherical mesoporous silicas аs drug delivery carriers. Int J Pharm 436:778–785

    Article  Google Scholar 

Download references

Acknowledgements

The authors are thankful to the post-graduate office of Guilan University for the support of this work.

Author information

Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Guilan, P.O. Box 1914, Rasht, Iran

    Laleh Latifi & Shabnam Sohrabnezhad

Authors
  1. Laleh Latifi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shabnam Sohrabnezhad
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shabnam Sohrabnezhad.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Latifi, L., Sohrabnezhad, S. Influence of pore size and surface area of mesoporous silica materilas (MCM-41 and KIT-6) on the drug loading and release. J Sol-Gel Sci Technol 87, 626–638 (2018). https://doi.org/10.1007/s10971-018-4742-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10971-018-4742-7

Keywords

Search

Navigation