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An update on Glycerophosphodiester Phosphodiesterases; From Bacteria to Human

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Abstract

The hydrolysis of deacylated glycerophospholipids into sn-glycerol 3-phosphate and alcohol is facilitated by evolutionarily conserved proteins known as glycerophosphodiester phosphodiesterases (GDPDs). These proteins are crucial for the pathogenicity of bacteria and for bioremediation processes aimed at degrading organophosphorus esters that pose a hazard to both humans and the environment. Additionally, GDPDs are enzymes that respond to multiple nutrients and could potentially serve as candidate genes for addressing deficiencies in zinc, iron, potassium, and especially phosphate in important plants like rice. In mammals, glycerophosphodiesterases (GDEs) play a role in regulating osmolytes, facilitating the biosynthesis of anandamine, contributing to the development of skeletal muscle, promoting the differentiation of neurons and osteoblasts, and influencing pathological states. Due to their capacity to enhance a plant's ability to tolerate various nutrient deficiencies and their potential as pharmaceutical targets in humans, GDPDs have received increased attention in recent times. This review provides an overview of the functions of GDPD families as vital and resilient enzymes that regulate various pathways in bacteria, plants, and humans.

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Funding

This study financially supported by the Tabriz University of Medical Sciences, Tabriz, Iran (Grant No., 74063).

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Authors and Affiliations

  1. Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Seyyedeh Mina Hejazian, Sepideh Zununi Vahed & Seyed Mahdi Hosseiniyan Khatibi

  2. Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

    Saeed Pirmoradi & Seyed Mahdi Hosseiniyan Khatibi

  3. Faculty of Electrical Engineering, K.N. Toosi University of Technology, Tehran, Iran

    Saeed Pirmoradi

  4. Bangladesh Rice Research Institute, Dhaka, Bangladesh

    Ripon Kumar Roy

Authors
  1. Seyyedeh Mina Hejazian
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  2. Saeed Pirmoradi
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  3. Sepideh Zununi Vahed
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  4. Ripon Kumar Roy
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  5. Seyed Mahdi Hosseiniyan Khatibi
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Contributions

Conceptualization: SZV, RKR, SMHKh, Data curation: RKR, SMHKh, Resources: SMH, Supervision: SMHKh, Writing-original draft: SZV, SP, RKR, SMHKh, Writing, review, and editing: SMH, SZV, SP, RKR, SMHKh.

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Correspondence to Seyed Mahdi Hosseiniyan Khatibi.

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Hejazian, S.M., Pirmoradi, S., Zununi Vahed, S. et al. An update on Glycerophosphodiester Phosphodiesterases; From Bacteria to Human. Protein J (2024). https://doi.org/10.1007/s10930-024-10190-4

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