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ABC Exporters in Pathogenesis: Role of Synthetic Anti-Microbial Peptides

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Abstract

ABC exporters are involved in diverse cellular processes including lipid trafficking, drug resistance, pathogenesis etc. The greatest thrust has been in the area of drug resistance that explains the underlying well-crafted canonical architecture of its structure. Interestingly, ranging from structural organisation to subsequent design and delivery aspects lays the niche of antimicrobial peptides. One of the major highlight of this paper is the role of synthetic antimicrobial peptides in current scenario.

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Abbreviations

ABC:

ATP binding cassette

ALD:

Adrenoleukodystrophy

AMPs:

Antimicrobial peptides

CFTR:

Cystic fibrosis transmembrane conductance regulator

MATE:

Multidrug and toxin compound extrusion

MDR:

Multi drug resistance

MFS:

Major facilitator superfamily

MMP7:

Matrix metalloproteinase 7

NBD:

Nucleotide binding domain

OABP:

Organic anion binding protein

PACE:

Proteobacterial antimicrobial compound efflux

PXE:

Pseudoxanthoma elasticum

RND:

Resistance nodulation division

SMR:

Small multidrug resistance

SUR:

Sulfonylurea receptor

TAP:

Transporters associated with antigen processing

TMD:

Transmembrane domain

TMH:

Transmembrane helices

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Funding

Funding was provided by Department of Biotechnology, Ministry of Science and Technology (Grant No. Intramural), Government of India.

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  1. National Centre for Cell Science, NCCS Complex, Ganeshkhind, Pune, 411007, India

    Ritika Kabra & Shailza Singh

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  1. Ritika Kabra
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Correspondence to Shailza Singh.

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Kabra, R., Singh, S. ABC Exporters in Pathogenesis: Role of Synthetic Anti-Microbial Peptides. Protein J 39, 657–670 (2020). https://doi.org/10.1007/s10930-020-09931-y

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