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Selective Laser Sintering PLA/Mg Composite Scaffold with Promoted Degradation and Enhanced Mechanical

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Abstract

Polylactic acid (PLA) is widely used in the treatment of bone defects due to its good properties, but the problem of its slow degradation rate needs to be solved urgently. In this study, different proportions of Mg were introduced into PLA to promote and regulate its degradation. A three-dimensional porous composite bone scaffold made of PLA and Mg was prepared using selective laser sintering (SLS). Degradation results showed that the weight loss rate of the Mg-containing scaffold within 4 weeks was nearly five times higher than that of the pure PLA scaffold. Moreover, the degradation mechanism was further explored, and it was believed that the addition of Mg could consume the acidic degradation products of PLA, thus destroying the integrity of the PLA molecular chain and accelerating the flow of the molecular chain, ultimately forming a cycle that promotes degradation. In addition, the magnesium-containing scaffold (PLA/3Mg) also showed good compressive strength (5.6 MPa), which was nearly twice as high as that of the pure PLA scaffold (2.67 MPa). Therefore, we believe that introducing an appropriate amount of Mg can better adjust the balance between the degradation and mechanical properties of PLA scaffolds.

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Acknowledgements

(1) Natural Science Foundation of Hunan Provincial (2022JJ50182); (2) Scientific Research Foundation of Hunan Provincial Education Depart-ment (21B0686); (3) Research Foundation of Shaoyang Science and Technology Bureau(2021GZ041); (4) Graduate Research and Innovation Project of Shaoyang University (CX2022SY059).

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Authors and Affiliations

  1. Key Laboratory of Hunan Province for Efficient Power System and Intelligent Manufacturing, College of Mechanical and Energy Engineering, Shaoyang University, Shaoyang, 422000, China

    Mengqi Li, Hai Yuan, Wenhao Ding, Haocheng Du, Xiaoping Guo, Dongying Li & Yong Xu

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Li, M., Yuan, H., Ding, W. et al. Selective Laser Sintering PLA/Mg Composite Scaffold with Promoted Degradation and Enhanced Mechanical. J Polym Environ (2024). https://doi.org/10.1007/s10924-024-03208-6

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