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Fabrication and Investigation of Oxidized-β-Cyclodextrin Nanoparticle as a Novel Class pH Responsive Drug Delivery Vehicle

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Abstract

Oxidized β-cyclodextrin (O-β-CD) nanoparticle was synthesized using oxidation process and Amoxicillin trihydrate (AMOX) model drug was integrated both via Schiff base reaction (C=N bond) as well as inclusion into cavity of O-β-CD to evaluate pH-responsive drug release behavior. The drug loaded nanocarrier (AM-O-β-CD) was characterized and results showed this formation, encapsulation and morphological change with average particle size (398 ± 8.51 nm), negative zeta potential values (− 25.4 ± 1.54) and high entrapment efficiency (86.1%). The in vitro release behavior of AM-O-β-CD was evaluated in physiological buffer conditions (0.1 M PBS, pH 5.2, at 37 °C). It was found that drug-loaded AM-O-β-CD showed sustain, prolonged much higher drug release profile (94.72%) in low pH than that of the pure drug (24.18%) in the same acidic medium. Release kinetics of drug loaded AM-O-β-CD was determined according to well-known mathematical models, revealing that in vitro release profile could be best expressed by Higuchi kinetic model as release data showed the highest linearity (R2 = 0.967) so that drug release takes place due to both dissolution and diffusion as it is expected. As a result, it has been proven that the nanostructure has the potential to be pH sensitive drug carrier, especially for drugs containing NH2 side groups in acidic environments.

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Funding

This research was funded by Ondokuz Mayıs University under Scientific Research (BAP) project (Project Number: PYO. FEN.1901.19.003).

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Authors and Affiliations

  1. Department of Nanoscience and Nanotechnology, Graduate School of Natural and Applied Sciences, Ondokuz Mayıs University, 55200, Kurupelit, Samsun, Turkey

    Ayhan Bergal

  2. Department of Chemistry, Faculty of Science and Literature, Ondokuz Mayıs University, 55200, Kurupelit, Samsun, Turkey

    Muberra Andac

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AB: Resources, Data curation, Investigation, Validation, Manuscript drafting, Writing—original draft. MA: Resources, Project administration, Validation; Supervision.

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Correspondence to Ayhan Bergal.

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Bergal, A., Andac, M. Fabrication and Investigation of Oxidized-β-Cyclodextrin Nanoparticle as a Novel Class pH Responsive Drug Delivery Vehicle. J Polym Environ (2023). https://doi.org/10.1007/s10924-023-03082-8

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