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Enhanced Performance of Aloe vera-Incorporated Bacterial Cellulose/Polycaprolactone Composite Film for Wound Dressing Applications

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Abstract

Recently, biopolymers have become a resource for the biomedical material field due to its biocompatibility and biodegradability. In this work, Aloe vera-loaded bacterial cellulose- and polycaprolactone -based composites were successfully prepared for wound dressing applications. The structural, morphological, thermal, swelling, and degradation properties were investigated. Result showed that the addition of Aloe vera resulted in a strong peak characteristic of hydroxyl groups and amide I by attenuated total reflectance-Fourier transform infrared analysis. Pores were present inside the composite structure and varied with the Aloe vera content. No crystallinity peak of Aloe vera was observed. Thermogravimetric analysis indicated a slight change in the thermal decomposition temperature and a loss of water molecules below 100 °C. The swelling and weight loss behaviour were remarkably changed when only 5% Aloe vera was loaded into the composite. Moreover, Aloe vera enhanced the toughness and elongation of the composite. All the composites exhibited a burst release profiles within 60 min. The MTT assay showed a concerningly low cell viability concerning the amount of Aloe vera loaded into the composite. Therefore, Aloe vera-loaded BC and PCL composites could be developed for wound dressing applications.

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Acknowledgements

This work was financially supported by the Thailand Science Research and Innovation (TSRI), Chulabhorn Research Institute (Grant No. 313/2229) and the Thammasat University Research Unit in Textile and Polymer Chemistry.

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Authors and Affiliations

  1. Faculty of Science and Technology, Department of Materials and Textile Technology, Thammasat University, Pathumthani, Thailand

    Pornsuda Kotcharat & Sarute Ummartyotin

  2. Laboratory of Organic Synthesis, Chulabhorn Research Institute, Bangkok, Thailand

    Piyachat Chuysinuan, Thanyaluck Thanyacharoen & Supanna Techasakul

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  1. Pornsuda Kotcharat
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  2. Piyachat Chuysinuan
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  3. Thanyaluck Thanyacharoen
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Correspondence to Sarute Ummartyotin.

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Kotcharat, P., Chuysinuan, P., Thanyacharoen, T. et al. Enhanced Performance of Aloe vera-Incorporated Bacterial Cellulose/Polycaprolactone Composite Film for Wound Dressing Applications. J Polym Environ 30, 1151–1161 (2022). https://doi.org/10.1007/s10924-021-02262-8

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