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A Novel Aloe Vera-Loaded Ethylcellulose/Hydroxypropyl Methylcellulose Nanofibrous Mat Designed for Wound Healing Application

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Abstract

Newly, the usage of nanofibers (NFs) as wound dressings with the aim of their rapid healing and prevention of bacterial infection has been considered by researchers. In this regard, we produced the ethylcellulose/hydroxypropyl methylcellulose NFs incorporated with Aloe-vera (EC/HPMC/Alv) by the electrospinning technique. The produced NFs were investigated for their chemical structure, morphological, mechanical, degradation, swelling, cell viability, and antibacterial properties. Amongst the produced NFs, the NF samples containing 10% Alv illustrated the appropriate mechanical properties. The produced NFs did not show any cell cytotoxicity which indicates their good compatibility. Also, NFs containing Alv significantly (P < 0.05) increased cell proliferation and adhesion. In addition, the NFs/Alv sample was indicated antibacterial ability against Staphylococcus aureus (10.21 ± 1.21 mm) and Escherichia coli (5.06 ± 1.3 mm) pathogenic bacteria. As a result, these findings suggest that the produced NFs could be applied as an active mat for wound dressing application.

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Acknowledgements

This research was supported by the Nutrition Research Center; Tabriz University of Medical Sciences (Grant Number: 67160).

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Authors and Affiliations

  1. Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Zahra Mohebian & Marjan Ghorbani

  2. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Issa Tajmohammadi & Marjan Ghorbani

  3. Student Research Committee, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran

    Leila Yavari Maroufi

  4. Nanofiber Research Center, Asian Nanostructures Technology Co. (ANSTCO), Zanjan, Iran

    Soghra Ramezani

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  1. Zahra Mohebian
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  2. Issa Tajmohammadi
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Correspondence to Marjan Ghorbani.

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Mohebian, Z., Tajmohammadi, I., Yavari Maroufi, L. et al. A Novel Aloe Vera-Loaded Ethylcellulose/Hydroxypropyl Methylcellulose Nanofibrous Mat Designed for Wound Healing Application. J Polym Environ 30, 867–877 (2022). https://doi.org/10.1007/s10924-021-02240-0

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